Evidence map›Paper›PMID 40842424›Full record

ArticlePhysiological reports2025

Neuromuscular fatigue reduces force responsiveness when controlling leg external forces.

Pawel Kudzia, James M Wakeling, Stephen N Robinovitch, J Maxwell Donelan

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pawel KudziaDepartment of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0002-6667-2913
James M WakelingDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Stephen N RobinovitchDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
J Maxwell DonelanDepartment of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada.

Funding

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) PGSD3 518447 2018Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN 2020 04638
6 · The paper itself

Abstract

Agile movement requires precise control of ground reaction forces, yet the impact of neuromuscular fatigue on this control remains incompletely understood. We investigated how leg muscle fatigue affects the nervous system's ability to modulate vertical ground reaction forces, hypothesizing that fatigue would impair responsiveness, and accuracy. Eighteen healthy participants (11 W, 7 M; age: 26 ± 3.8 yr) performed force-matching tasks using a custom apparatus that constrained body movement while allowing isolated leg force production. Participants force matched visual step targets before and after fatigue, which we induced by sustained submaximal contractions. We then quantified responsiveness (rise time, bandwidth) and accuracy (overshoot, steady-state error, variability). Fatigue reduced MVC force by 26.1 ± 12.3% (from 2.95 ± 0.58 to 2.20 ± 0.47 body weights; p = 4.70e-6) and impaired responsiveness, with rise time increasing 23.3 ± 41.0% (from 303 ± 100 to 373 ± 94 ms; p = 6.00e-4) and bandwidth decreasing 25.2 ± 17.5% (from 1.33 ± 0.60 to 1.00 ± 0.25 Hz; p = 4.83e-2). Notably, accuracy remained largely unchanged, with only a transient decrease in overshoot from 4.30 ± 2.62% to 2.56 ± 1.19% (p = 0.047). These findings show neuromuscular fatigue selectively impairs the speed of leg force adjustments while preserving accuracy, possibly through compensatory strategies. This dissociation has implications for understanding motor control deficits and injury risk during fatigue.

Indexed as

LegMuscle FatigueMuscle, SkeletalAdultFemaleHumansMaleMovementMuscle ContractionYoung Adultforce modulationground reaction forcesinjury preventionmotor controlneuromuscular fatigueresponsiveness

Identifiers

PMID40842424
PMCPMC12371267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.