Evidence map›Paper›PMID 40842414›Full record

ArticleHLA2025

Maternal-Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders in a Genetically Isolated Population.

Liseanne J Van't Hof, Marie-Louise P van der Hoorn, Selena Migdis, Geert W Haasnoot, Emma T M Peereboom, Eric Spierings, Pieter J E van der Linden, Jacqueline D H Anholts, Heleen de Vreede, Winnie Ottenhof and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HLA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liseanne J Van't HofDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-1756-3825
Marie-Louise P van der HoornDepartment of Obstetrics and Gynaecology, Leiden University Medical Center, Leiden, the Netherlands.
Selena MigdisDepartment of Obstetrics and Gynaecology, Leiden University Medical Center, Leiden, the Netherlands.
Geert W HaasnootDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Emma T M PeereboomCenter for Translational Immunology, University Medical Center Utrecht, the Netherlands.
Eric SpieringsCenter for Translational Immunology, University Medical Center Utrecht, the Netherlands.ORCID 0000-0001-9441-1019
Pieter J E van der LindenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Jacqueline D H AnholtsDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Heleen de VreedeWaterland Oost Midwifery Practice, Volendam, the Netherlands.
Winnie OttenhofWaterland Oost Midwifery Practice, Volendam, the Netherlands.
Dave L RoelenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-1846-1193
Michael EikmansDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Inge B MathijssenDepartment of Human Genetics, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Lisa E E L O LashleyDepartment of Obstetrics and Gynaecology, Leiden University Medical Center, Leiden, the Netherlands.

Funding

Leids Universitair Medisch Centrum
6 · The paper itself

Abstract

In pregnancy, semi-allogenic foetal trophoblasts express a specific HLA profile mediating maternal leukocyte contact, crucial for placentation. Paradoxically, maternal immunomodulation requires foetal antigen recognition, especially involving certain HLA molecules. Pre-eclampsia, a severe hypertensive complication, has been linked to antigenic similarity. Previously, we showed no selection for HLA (in)compatibility in uncomplicated naturally conceived pregnancies. However, pre-eclamptic pregnancies were associated with increased total maternal-foetal HLA and HLA-C matching. These associations suggest a role for HLA mismatches in immune regulation leading to an uncomplicated pregnancy. To better understand HLA homozygosity in human reproduction, we aimed to determine if there is a preferential selection for HLA compatibility in a genetically isolated population, and its relation to hypertensive complications. A nested case-control study, comprising 125 uncomplicated pregnancies and 50 with hypertensive complications (29 with pregnancy-induced hypertension, 21 with pre-eclampsia) was conducted in a genetically isolated Dutch population (F

Indexed as

Histocompatibility, Maternal-FetalHLA-DQ beta-ChainsHypertension, Pregnancy-InducedPre-EclampsiaAdultAllelesCase-Control StudiesFemaleGenotypeHistocompatibility TestingHumansPregnancyReceptors, KIRHLA-DQB1 antigenHLA-DQ beta-ChainsReceptors, KIRgenetic phenomenagenetic variationinbreedingKIR receptorsmaternal–foetal histocompatibilitymolecular epidemiologypre‐eclampsiapregnancypregnancy‐induced hypertension

Identifiers

PMID40842414
PMCPMC12371389

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.