Evidence map›Paper›PMID 40842332›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2025

Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.

Nada Borghol, Sozerko Yandiev, Julien Courchet

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nada BorgholUniv Lyon, Univ Lyon 1, CNRS, INSERM, Physiopathologie Et Génétique du Neurone et Du Muscle, UMR5261, U1315, Institut NeuroMyoGène, Lyon, France.ORCID https://orcid.org/0009-0005-7416-5646
Sozerko YandievUniv Lyon, Univ Lyon 1, CNRS, INSERM, Physiopathologie Et Génétique du Neurone et Du Muscle, UMR5261, U1315, Institut NeuroMyoGène, Lyon, France.
Julien CourchetUniv Lyon, Univ Lyon 1, CNRS, INSERM, Physiopathologie Et Génétique du Neurone et Du Muscle, UMR5261, U1315, Institut NeuroMyoGène, Lyon, France.ORCID https://orcid.org/0000-0002-1199-9329

Funding

Association Française contre les Myopathies AFM-Telethon through the strategic MyoNeurALP allianceEuropean Research Council 101157728-ABC-MTFondation pour la Recherche Medicale FDT202404018406LABEX CORTEX ANR-11-LABX-0042/ANR-11-IDEX-0007
6 · The paper itself

Abstract

Recent advances in genomics uncovered a large number of microproteins, which are peptides of less than 100 amino-acids encoded by small open reading frames. In contrast to their identification, the validation of the functions of microproteins remains challenging. Especially, what are their biological functions in the cell and how this relates to disease conditions are still largely unknown. Although microproteins ensure a plethora of cellular functions, recent evidence demonstrate that they may disproportionately affect cellular metabolism. In this review, we will address the roles of mitochondrial-targeted microproteins, and especially how this class of protein regulates neuronal metabolism in neurodevelopment and neurodegeneration, and may contribute to axonal and dendritic metabolic disorders.

Indexed as

MitochondriaMitochondrial ProteinsNeurodegenerative DiseasesAnimalsHumansMicropeptidesNeuronsMicropeptidesMitochondrial Proteinsmetabolismmicroproteinsmitochondrianeurodegenerationneurodevelopmentneuron

Identifiers

PMID40842332
PMCPMC12455275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.