Trial reportThoracic cancer2025
Three-Year Follow-Up of the Phase II Trial for Resectable Non-Small-Cell Lung Cancer Treated With Perioperative Sintilimab and Neoadjuvant Anlotinib Plus Chemotherapy: TD-NeoFOUR Trial.
Trial report in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundLung cancer is a leading cause of cancer-related deaths. Perioperative therapies, including neoadjuvant chemo-immunotherapy, have improved outcomes, but combining them with antiangiogenic drugs may offer further benefits. This study evaluated the 3-year efficacy and safety of neoadjuvant sintilimab, anlotinib, and chemotherapy in resectable NSCLC patients from the TD-NeoFOUR trial.
methodsThe study included 45 patients who received neoadjuvant treatment with anlotinib, sintilimab, and platinum-based chemotherapy. The primary endpoint was overall survival (OS), and the secondary endpoint was event-free survival (EFS). The Kaplan-Meier method was used to estimate survival curves, and the log-rank test was used to compare survival rates between subgroups.
resultsAs of November 11, 2024, all 45 patients had been followed up for a median of 35.7 months. The estimated 3-year EFS rate was 84.3%, and the estimated 3-year OS rate was 86.7%. Subgroup analysis showed that patients achieving pathological complete response (pCR) and major pathological response (MPR) had significantly higher 3-year EFS and OS rates compared to patients with non-pCR and non-MPR. No new treatment-related adverse events (TRAEs) occurred during the 3-year follow-up, indicating the long-term safety of the treatment regimen.
conclusionsThe combination of neoadjuvant chemo-immunotherapy and antiangiogenic drugs significantly improved long-term survival outcomes in patients with resectable NSCLC. This treatment regimen is a promising option for improving prognosis in this patient population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.