Evidence map›Paper›PMID 40842278›Full record

ArticleThe Journal of infectious diseases2026

Schistosome Infection is Associated With High-Risk Human Papillomavirus Persistence, Together With Altered Cervicovaginal Microbiota.

Crispin Mukerebe, Alexandra A Cordeiro, Christine Aristide, Soledad Colombe, Brooke W Bullington, Samuel Kalluvya, Govert J van Dam, Claudia J de Dood, Paul L A M Corstjens, Jane K Maganga and 5 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Crispin MukerebeMwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania.ORCID 0009-0001-6128-8840
Alexandra A CordeiroCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-3777-8911
Christine AristideCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Soledad ColombeCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Brooke W BullingtonCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Samuel KalluvyaDepartment of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania.
Govert J van DamLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Claudia J de DoodDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Paul L A M CorstjensDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0004-0526
Jane K MagangaMwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania.
John M ChangaluchaMwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania.
Lucy A NamkingaSt. Francis College of Health and Allied Sciences, Department of Internal Medicine, Pharmacology and Psychiatry, Ifakara, Tanzania.
Victor Anacletus MakeneDepartment of Molecular Biology and Biotechnology, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania.
Myung Hee LeeCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Jennifer A DownsMwanza Intervention Trials Unit/National Institute for Medical Research, Mwanza, Tanzania.ORCID 0000-0001-9537-204X

Funding

Genital Immune, Mucosal, and Viral Effects of Female Genital Schistosomiasis in TanzaniaR01AI168306 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jennifer Alzos Downs · 2022 to 2026
$3.1M
Post-Doctoral Fellowship Training in HIV Clinical InvestigationD43TW011826 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI Daniel W Fitzgerald, Saidi Kapiga · 2021 to 2026
$1.9M
Schistosomiasis and Women's Reproductive HealthK24AI182638 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jennifer Alzos Downs · 2024 to 2026
$611k
Research Training Program in Reproductive and Sexual HealthR25HD115514 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JESSICA N SANDERS, David Turok · 2024 to 2026
$474k
FIC NIH HHS D43 TW 011826FIC NIH HHS D43 TW011826National Institute of Allergy and Infectious Diseases K24 AI 182638National Institute of Allergy and Infectious Diseases R01 AI 168306NIAID NIH HHS K24 AI182638NIAID NIH HHS R01 AI168306NICHD NIH HHS R25 HD115514NIH HHS
6 · The paper itself

Abstract

Schistosoma haematobium infection may impair female genital mucosal antiviral defense. We sought to determine whether women with S. haematobium infection had higher odds of high-risk human papillomavirus (HR-HPV) persistence, a prerequisite to cervical cancer. We also examined cervicovaginal dysbiosis, which has been linked to HR-HPV persistence and schistosome infection. In 96 Tanzanian women with baseline and 9- to 12-month follow-up samples, we performed HPV genotyping, schistosome antigen quantification, and 16S rRNA sequencing. Both S. haematobium (odds ratio: 4.7 [1.3-16.5], P = .017) and Gardnerella-dominant microbiome (P = .049) were associated with HR-HPV persistence, suggesting these factors may contribute to high cervical cancer rates in Africa.

Indexed as

Cervix UteriMicrobiotaPapillomaviridaePapillomavirus InfectionsSchistosomiasis haematobiaVaginaAdultAnimalsDysbiosisFemaleGenotypeHuman Papillomavirus VirusesHumansMiddle AgedRNA, Ribosomal, 16SSchistosoma haematobiumRNA, Ribosomal, 16Scervicovaginal dysbiosishigh-risk human papillomavirusS. haematobium

Identifiers

PMID40842278
PMCPMC12741867

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.