ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025
Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.
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Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- Article
- Triple-Survival Stereotactic Brain Surgeries for the Intracranial Injections of Glioblastoma Stem-like Cells and Oncolytic Herpes Simplex Viruses.Methods and protocols · 2026Article
- sMICA/sMICB and Immune Checkpoint in Endometriosis: Toward a Minimally Invasive Diagnostic Model Based on Machine Learning.Biomedicines · 2026Article
- CCAAT/enhancer-binding protein delta regulates miRs-4257 and 3156 to attenuate the interleukin 12 through small extracellular vesicle transmission in glioblastoma.Cancer cell international · 2026Article
Corrections and comments
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Authors and funding
24 authors.
Taral R LunavatMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Biomedicine, University of Bergen, 5019 Bergen, Norway.
Lisa NielandMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Sanne M van de LooijMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Alexandra J E M de ReusMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Charles P CouturierBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Institute of Medical Engineering and Sciences and Department of Chemistry, Massachusetts Institute Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institutes of Technology, Cambridge, MA 02139, USA; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada.
Chadi A El FarranBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA.
Tyler E MillerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Ludwig Center at Harvard Medical School, Boston, MA 02215, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Julia K LillCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Maryam SchübelCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Tianhe XiaoMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Emilio Di IanniMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Elliot C WoodsBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Yi SunBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
David Rufino-RamosMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Thomas S van SolingeMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Shadi MahjoumMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Emily GrandellMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Mao LiDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Vamsi MangenaHarvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.
Gavin P DunnDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Brain Tumor Immunology and Immunotherapy Program, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Russell W JenkinsBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Thorsten R MempelCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Xandra O BreakefieldMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Koen BreyneMolecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. Electronic address: kbreyne@mgh.harvard.edu.
Funding
The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHIOCCA, E. ANTONIO · 1996 to 2021
$30.9MTransfer of microRNA regulators from glioblastoma to brain microenvironment U19CA179563 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHAREST, ALAIN · 2013 to 2017
$8.6MStrategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI SARTOR, MAUREEN AGNES · 2019 to 2023
$8.4MThe power of extracellular vesicles in glioblastomaR35CA232103 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2018 to 2024
$6.9MCellular mechanisms by which exhausted T cell responses are restoredR01AI123349 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Thorsten Roman Mempel · 2017 to 2026
$4.5MImmuno-Cell Therapy for Brain TumorsR01NS122163 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI XANDRA OWENS BREAKEFIELD · 2022 to 2026
$2.9MCue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck CancersR01CA278212 · NCI · YALE UNIVERSITY · PI Sara Isabel Pai · 2024 to 2026
$2.0MLeica Stellaris 8 Falcon confocal microscopeS10OD036287 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI MEMPEL, THORSTEN ROMAN · 2024 to 2024
$873kBoosting IL-12-induced anti-glioblastoma activity via immunotherapeutic extracellular vesicles.K22CA282019 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Koen Breyne · 2024 to 2026
$482kNCI NIH HHS K22 CA282019NCI NIH HHS P01 CA069246NCI NIH HHS P01 CA240239NCI NIH HHS R01 CA278212NCI NIH HHS R35 CA232103NCI NIH HHS U19 CA179563NIAID NIH HHS R01 AI123349NIH HHS S10 OD036287NINDS NIH HHS R01 NS122163
Abstract
The standard of care in high-grade gliomas has remained unchanged in the past 20 years. Efforts to replicate effective immunotherapies in non-cranial tumors have led to only modest therapeutical improvements for patients with glioma. Here, we demonstrate that intratumoral (i.t.) administration of recombinant interleukin-12 (rIL-12) promotes local cytotoxic CD8
Indexed as
4-1BB LigandBrain NeoplasmsGliomaInterleukin-12AnimalsCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsDependovirusDisease Models, AnimalGenetic VectorsHumansImmunotherapyMiceTumor Microenvironment4-1BB LigandInterleukin-124-1BBLAAV vectorcytotoxic CD8 T cellsgene therapyglioblastomaIL-12immunotherapy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.