ReviewBrain and behavior2025
Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta-Analysis.
Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness.Frontiers in aging neuroscience · 2026Pooled it
- Symptomatic treatment for Alzheimer disease: current evidence and future directions.Nature reviews. Neurology · 2026Review
- Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise.Cureus · 2025Review
- Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta-Analysis.Brain and behavior · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundMild cognitive impairment (MCI) is considered a preclinical or prodromal stage of Alzheimer's disease (AD). MCI patients have an annual probability of progression to dementia of 10%-15%, far higher than the normal elderly (∼1%-2%). We conducted a network meta-analysis (NMA) on the efficacy of various exercise modes on MCI adults.
methodsA computer search was conducted in Embase, PubMed, the Cochrane Library, and Web of Science for RCTs on the effects of exercise training on MCI patients from their inception to February 22, 2025. Two reviewers were independently responsible for study screening, data extraction, and quality assessment. RevMan 5.4, Stata15, and R4.4.1 were utilized for data analysis.
resultsThirty-five studies with 2717 patients were included. The NMA results revealed that combination training (CT) performed best in increasing the MoCA and MMSE scores of MCI patients, with SUCRA of 99.43% and 87.04%, respectively. Resistance training and sensorimotor training were the second-best interventions for increasing MMSE and MoCA scores, respectively.
conclusionCT is the best intervention to improve MOCA and MMSE scores in patients with MCI, which can effectively alleviate the disease progression of MCI. However, a variety of double-blind, large-sample clinical trials are still needed to further verify this conclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.