SynthesisBrain and behavior2025
Experimental Evidence on Acupuncture Targeting Ferroptosis for Neurological Function Improvement in Cerebral Stroke: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experimental Evidence on Acupuncture Targeting Ferroptosis for Neurological Function Improvement in Cerebral Stroke: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Phytochemical and Anti-Ischemic Stroke Properties from theDrug design, development and therapy · 2026Review
- Neurobiological mechanisms of acupuncture for post-ischemic stroke comorbid insomnia and cognitive impairment: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAcupuncture, a traditional Chinese medicinal practice, has been studied for its ability to regulate ferroptosis and improve neurological function. This systematic review aimed to evaluate the evidence about the effects of acupuncture on ferroptosis and the improvement of neurological function in animal models of cerebral stroke.
methodsThe research was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA 2020) guidelines. We conducted a literature search in web of science, Embase, Ebsco, PubMed, Cochrane library, China biomedical literature database (CBM), China national knowledge infrastructure (CNKI), Wanfang database (WF), and VIP database for Chinese technical periodicals, covering pertinent studies up to May 30, 2024. The inclusion criteria covered experimental animal models of cerebral stroke that underwent acupuncture interventions (electroacupuncture [EA], manual acupuncture [MA], or moxibustion [Moxi]). The primary outcomes consisted of neurological function scores (Longa, modified neurological severity score [mNSS], Zausinger, Garcia, Ludmila Belayev scores, and levels of brain-derived neurotrophic factor [BDNF]). Secondary outcomes encompassed iron metabolism (iron ion content, ferritin heavy chain 1 [FTH1], transferrin receptor 1 [TFR1]), lipid peroxidation (malondialdehyde [MDA], reactive oxygen species [ROS]), antioxidative parameters (glutathione peroxidase 4 [GPX4], glutathione [GSH], superoxide dismutase [SOD]), and ferroptosis markers (long-chain acyl-CoA synthetase 4 [ACSL4]). Two authors independently evaluated the methodological quality of the included studies utilizing the collaborative approach to meta-analysis and review of animal data from experimental studies (CAMARADES) 10-item checklist.
resultsThe meta-analysis indicated that acupuncture markedly enhanced neurological function scores (Longa, Longa [mNSS], Zausinger, Garcia, Ludmila Belayev) and elevated levels of BDNF, GSH, GPX4, and SOD in animal models of cerebral stroke. Furthermore, it significantly reduced the levels of cerebral iron, FTH1, TFR1, MDA, ROS, and ACSL4.
conclusionsAcupuncture effectively inhibits ferroptosis and enhances neurological function in animal models of cerebral stroke by modulating brain iron metabolism, decreasing lipid peroxidation, and improving brain antioxidant capacity.
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