Evidence map›Paper›PMID 40841998›Full record

SynthesisBMC cardiovascular disorders2025

Cusp-overlap view versus three cusp coplanar view during transcatheter aortic valve replacement using self-expandable valves: a systematic review, meta-analysis and meta-regression.

Basma Badrawy Khalefa, Ahmed K Awad, Ahmed R Gonnah, Mazen Negmeldin Aly Yassin, Nada G Hamam, Hatem Eldeeb, Mohamed Ramadan, Ali Dway, Karim Alsalhi, Mohamed T Osman and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Basma Badrawy KhalefaFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed K AwadFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed R GonnahImperial College Healthcare NHS Trust, London, UK.
Mazen Negmeldin Aly YassinFaculty of Medicine, Cairo University, Cairo, Egypt.
Nada G HamamFaculty of Medicine, Cairo University, Cairo, Egypt.
Hatem EldeebFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed RamadanFaculty of Medicine, Suez University, Suez, Egypt.
Ali DwayFaculty of Medicine, Al-Andalus University for Medical Sciences, Tartus, Syria.
Karim AlsalhiFaculty of Medicine, Batterjee Medical College, Jeddah, Saudi Arabia.
Mohamed T OsmanFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Basel F AlqeeqFaculty of Medicine, Islamic University of Gaza, Gaza, P480, Palestine. BaselMD@outlook.com.
Mohammed Al-TawilFaculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Serge SicouriDepartment of Cardiothoracic Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA, USA.
Massimo BaudoDepartment of Cardiothoracic Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA, USA.
Yoshiyuki YamashitaDepartment of Cardiothoracic Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA, USA.
Basel RamlawiDepartment of Cardiothoracic Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter aortic valve replacement (TAVR) is currently the treatment of choice for most patients with severe aortic stenosis. We conducted this meta-analysis to compare the outcomes of the cusp overlap technique (COT) versus the standard three-cusp technique during self-expandable valves implantation. We systematically searched PubMed, Scopus, Embase, Cochrane, and Web of Science (WOS) from inception to March 5, 2024. To estimate the effect size, dichotomous outcomes were pooled as RR, and continuous outcome was pooled as MD with their respective 95% CI. We included seventeen studies with a total of 3,129 patients in cusp-overlap technique (COT) arm and 2,818 patients in standard technique (ST) arm. The rate of 30-day mortality was borderline reduced in COT compared with ST, however, with no significant difference (RR = 0.61; 95% CI: [0.37-1.00], P = 0.05). Regarding conduction abnormalities, COT was related to lower risk of complete atrioventricular (AV) block (RR = 0.51; 95% CI: [0.37-0.69], P < 0.01), and permanent pacemaker implantation (PPM) (RR = 0.56; 95% CI: [0.46-0.70], P < 0.01). Mild to severe paravalvular leak (PVL) (RR = 1.00; 95% CI: [0.66-1.51], P = 1.00, I2 = 62%; P = 0.02) were comparable between COT and ST. Our study findings suggest that COT offers several advantages over ST, including reduced 30-day mortality, bleeding complications, and shorter procedural duration. The COT most importantly lowers the risk of conduction abnormalities, and hence the incidence PPM.

Indexed as

Aortic ValveAortic Valve StenosisHeart Valve ProsthesisTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFemaleHumansMalePostoperative ComplicationsProsthesis DesignRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeAortic stenosisCusp overlap technique (COT)Meta-analysisTranscatheter aortic valve replacement (TAVR)

Identifiers

PMID40841998
PMCPMC12369103

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.