Evidence map›Paper›PMID 40841986›Full record

ArticleStem cell research & therapy2025

Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation?

Leslie A Vallet, Marina Sánchez-Petidier, Romain Fernandes, Nataliia Naumova, Caterina Merla, Claudia Consales, Giorgia Innamorati, Franck M André, Lluis M Mir

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leslie A ValletMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France.
Marina Sánchez-PetidierMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France.
Romain FernandesMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France.
Nataliia NaumovaMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France.
Caterina MerlaDivision of Biotechnologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), 00123, Rome, Italy.
Claudia ConsalesDivision of Biotechnologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), 00123, Rome, Italy.
Giorgia InnamoratiDivision of Biotechnologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), 00123, Rome, Italy.
Franck M AndréMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France.
Lluis M MirMetabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches (METSY), UMR 9018, CNRS, Gustave Roussy, Université Paris-Saclay, PR2, 114 Rue Edouard Vaillant, 94805, Villejuif, France. luis.mir@cnrs.fr.ORCID http://orcid.org/0000-0002-8671-9467

Funding

European Commission FET OPEN H2020 964562
6 · The paper itself

Abstract

backgroundUnder regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca

methodsUsing fluorescence microscopy we evaluated the evolution of Ca

resultsAlthough the evolution of the Ca

conclusionsManipulating the frequency of Ca

Indexed as

Calcium SignalingCell CycleCell DifferentiationMesenchymal Stem CellsAdipogenesisAnimalsCalciumCell ProliferationCells, CulturedHumansOsteogenesisCalciumAdipogenic differentiationCalcium electroporationCalcium oscillations frequencyCell cycle controlCell proliferationElectrical stimulationElectropermeabilizationElectroporationMicrosecond pulsed electric fieldsOsteogenic differentiation

Identifiers

PMID40841986
PMCPMC12369127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.