Evidence map›Paper›PMID 40841926›Full record

ArticleJournal of the science of food and agriculture2025

Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk-derived osteopontin on male reproductive health in mice.

Chunyan Zhao, Guangqi Gao, Tao Zhang, Na Li, Yue Zhao, Zerong Lu, Yong Zhang, Zhihong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the science of food and agriculture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chunyan Zhao *Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.ORCID https://orcid.org/0009-0005-2646-5265
Guangqi Gao *Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Tao ZhangKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Na LiKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Yue ZhaoKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Zerong LuHealth and Happiness (H&H) Group, H&H Research, China Research and Innovation Center, Guangzhou, China.
Yong ZhangThe Fourth Medical Center of PLA General Hospital, Beijing, China.
Zhihong SunKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.ORCID https://orcid.org/0000-0002-7605-2048

Funding

Basic Research Operating Expenses Program for Colleges and Universities BR22-14-01Guangzhou Biostime Institute of Nutrition and Care 2022BINCMCF007National Natural Science Foundation of China 32325040
6 · The paper itself

Abstract

backgroundMale reproductive health is intricately linked to dietary components and gut microbiota balance. Osteopontin (OPN) deficiency and gut dysbiosis are associated with impaired spermatogenesis, yet the synergistic effects of probiotics and OPN remain unexplored.

resultsIn OPN-deficient mice, combined intervention with Bifidobacterium longum subsp. infantis B8762 and OPN increased gut microbiota alpha diversity and upregulated key reproductive genes (Etv4, Adamts16, Prok2, Gpr55, Rad54b). Testicular histology revealed restored spermatogenic cell density and seminiferous tubule integrity.

conclusionThis study demonstrates that co-administration of B8762 and OPN alleviates reproductive dysfunction via gut microbiota modulation and testicular gene regulation, offering a novel nutritional strategy for male fertility enhancement. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Bifidobacterium longum subspecies infantisMilkOsteopontinProbioticsAnimalsGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLReproductive HealthSpermatogenesisTestisOsteopontinBifidobacterium longum subsp. infantis B8762osteopontinreproductive healthSpp1

Identifiers

PMID40841926
PMCPMC12595393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.