ArticleBMC pregnancy and childbirth2025
Associations of CRP and PCT levels with obstetric and neonatal outcomes: a prospective study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigation of the association between maternal serum ferritin levels and preterm delivery: A systematic review and meta-analyses.Archives of gynecology and obstetrics · 2026Pooled it
- Association Between Maternal C-Reactive Protein (CRP) Levels and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Induction of Labour with Prostaglandins: Does Their Pro-Inflammatory Effect Mimic Chorioamnionitis After PROM?Geburtshilfe und Frauenheilkunde · 2026Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-reactive protein (CRP) and procalcitonin (PCT) levels may be elevated under inflammatory conditions. The aim of this study was to determine the cutoff values for CRP and PCT levels during pregnancy and to evaluate the associations of any elevation with obstetric and neonatal outcomes.
methodsThis prospective study was conducted from June 2023 to December 2024. The study included 411 singleton pregnant women aged 18-44 years with no apparent clinical infection. Venous blood samples were collected during the visit for routine antenatal care during all three trimesters. Categorical variables were compared between groups via the chi-square test, and Student's t-test was used to compare normally distributed continuous variables. The area under the ROC curve was used to detect sensitivity and specificity and to set a cutoff. Regression analysis was performed to evaluate the effects of age and BMI on obstetric complications. P values < 0.05 were considered statistically significant.
resultsThe mean CRP and PCT levels in the study group were 10.9 ± 16.7 and 0.17 ± 1.8, respectively. ROC curves were used to analyze the ability of CRP and PCT values during pregnancy to predict obstetric complications. A cutoff value of 6.72 mg/L (sensitivity: 67%; specificity: 60%) and 0.0385 (sensitivity: 60%; specificity: 61%) was revealed. The incidence of composite obstetric complications was significantly greater in patients with elevated CRP levels (32.4% vs. 67.6%) (p < 0.001). The incidence of preeclampsia, GHT, neonatal complications and the need for intensive care were significantly greater in patients with CRP levels > 6.72. The incidence of composite obstetric complications was significantly greater in patients with elevated PCT levels (59% vs. 41%) (p < 0.001). Patients with elevated PCT levels had a greater frequency of preterm labor or PPROM, neonatal complications, need for intensive care, and RDS.
conclusionsElevated CRP and PCT are associated with increased rates of obstetric and neonatal complications. CRP and PCT, which are inexpensive and available, may be used for screening to predict obstetric and neonatal complications during patient follow-up.
trial registrationThis study was approved by the institutional ethical committee of the Gazi University Faculty of Medicine (Approval No:05.06.2023/479).
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