ArticleBMC pulmonary medicine2025
The association between hemoglobin-to-red cell distribution width ratio and asthma and asthma exacerbations: a cross-sectional study.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Combined diagnostic value of rheumatoid arthritis-specific citrullinated protein, haemoglobin-to-red cell distribution width ratio, and anti-CCP antibody in rheumatoid arthritis.Annals of medicine · 2026Article
- Hemoglobin-to-Red cell distribution width ratio and asthma risk: cross-population validation and vitamin D mediation analysis.Frontiers in allergy · 2026Article
- Red Cell Distribution Width-to-Albumin Ratio as a Predictor of Preeclampsia in Advanced Maternal Age: A Retrospective Cohort Study.International journal of women's health · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hemoglobin-to-red cell distribution width ratio (HRR) is a newly identified inflammatory biomarker associated with various inflammatory diseases. Asthma is a major global health burden and an inflammatory airway disease significantly affected by inflammation. This study primarily aims to evaluate the relationship between HRR and asthma, as well as asthma-related outcomes, including stable asthma and asthma exacerbations in the past year.
methodsData from 2007 to 2023 were collected from the NHANES database. Multivariable logit and restricted cubic spline (RCS) analyses were conducted to elucidate the impact of HRR on asthma and its nonlinear relationship. Subgroup and interaction analyses were performed as part of the study's sensitivity analysis.
resultsThis study was based on an analysis of 13,343 individuals. According to logistic regression analysis, a higher HRR was associated with a lower likelihood of asthma (OR = 0.37, 95% CI: 0.23-0.6). Compared to the lowest group, the higher HRR group exhibited a 34% reduction in prevalence (OR = 0.66; 95% CI: 0.54-0.81, p < 0.01). According to RCS analysis, a linear relationship existed between HRR and asthmaprevalence. We further distinguished between stable asthma and acute exacerbations, and this association remained statistically significant.
conclusionThis study observed an inverse association between HRR and asthma. Specifically, an increase in HRR was significantly associated with a lower prevalence of stable asthma and acute exacerbation, providing potential evidence for the use of HRR in evaluating asthma status.
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