Evidence map›Paper›PMID 40841855›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.

Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
    Review
  4. Review
  5. Article
  6. Neuro-Cancer Interactions Shape Glioma Intratumoral Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tong WuCollege of Smart Materials and Future Energy, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.
Peiran ZhaoCollege of Smart Materials and Future Energy, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.
Zheng ChenDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, P. R. China.
Tianlei YingDepartment of Medical Microbiology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, P. R. China.
Zhihong NieThe State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200438, P. R. China.
Wei HuaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, P. R. China.
Huiyan LiCollege of Smart Materials and Future Energy, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.
Ying MaoDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, P. R. China.
Wenbo BuCollege of Smart Materials and Future Energy, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.ORCID https://orcid.org/0000-0001-6664-3453

Funding

Innovation Program of Shanghai Municipal Education Commission 2023ZKZD01Key Program of the National Natural Science Foundation of China 22235004Major Program of the National Natural Science Foundation of China T2495264National Science Foundation for the Young Scientists of China 52202346National Science Foundation for the Young Scientists of China 52302346
6 · The paper itself

Abstract

Glioma intratumoral heterogeneity remains a critical barrier to effective treatment, driving recurrence and resistance to therapy. Emerging evidence suggests that glioma cells acquire neural-like features through paracrine and synaptic communication with neural cells, fostering functional diversity within tumors. While neuro-cancer interactions are implicated in glioma heterogeneity, their precise roles remain incompletely synthesized. Here, by consolidating these discoveries, a conceptual framework is proposed for understanding the glioma intratumoral heterogeneity shaped by neuro-cancer interactions: cellular phenotypes, spanning neurogliomal synapses, glioma networks, and neuronal-like motility; and transcriptional states, which exhibit remarkable resemblance to neural cells. These diverse cellular phenotypes and transcriptional states synergistically fuel glioma progression, invasion, and resistance. By emphasizing the converging phenotypical and transcriptional evidence with spatial context within them, an underexplored but critical role of neuro-cancer interactions are proposed in glioma intratumoral heterogeneity. This provides potential strategies to explore and disrupt these neuro-cancer interactions, offering new insights to address glioma intratumoral heterogeneity for improved therapeutic outcomes.

Indexed as

Brain NeoplasmsGliomaHumanscancer neurosciencecellular phenotypefunctional adaptationintratumoral heterogeneitytranscriptional states

Identifiers

PMID40841855
PMCPMC12520531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.