ArticleScientific reports2025
Aqueous carbonic anhydrase-1 overexpression and its association with cytokine profiles and macular structural changes in retinal vein occlusion-associated macular edema.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The purpose was to evaluate aqueous carbonic anhydrase-1(CA-1) expression and explore its correlation with macular structural changes and other cytokines in patients with macular edema (ME) secondary to retinal vein occlusion (RVO). This was a retrospective cross-sectional study in which patients with RVO (n = 109) and control subjects (n = 37) were included. The concentrations of cytokines, including CA-1, PPK/PK, ICAM, bFGF, VEGF and MCP-1, in the aqueous humor were measured before intravitreal injection of anti-VEGF drugs or DEX drugs. We collected optical coherence tomography (OCT) images before obtaining aqueous humor. CA-1 levels in the aqueous humor were greater in the RVO group than in the control group, and CA-1 levels were lower in treated RVO patients than in treatment-naïve patients. In addition, the levels of other cytokines (PPK/PK, ICAM, bFGF, VEGF and MCP-1) tended to be similar to those of CA-1. CA-1 was positively correlated with visual acuity (VA) logMAR (r = 0.215; p = 0.03), PPK/PK (r = 0.58, p < 0.001), ICAM (r = 0.70, p < 0.001), bFGF (r = 0.48, p < 0.001), VEGF (r = 0.55, p < 0.001), MCP (r = 0.67, p < 0.001) and retinal hemorrhage (r = 0.309, p = 0.003) in RVO patients. In conclusion, CA-1 was overexpressed in RVO patients, especially in treatment-naïve patients. Additionally, increased CA-1 levels are associated with other aqueous cytokines, VA logMAR values and retinal hemorrhage in RVO patients.
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