Evidence map›Paper›PMID 40841797›Full record

ArticleAesthetic plastic surgery2026

The Impact of Postmastectomy Radiation Therapy on Immediate Prepectoral Reconstruction with Polyurethane-Coated Implants.

Marzia Salgarello, Valentina Sara Pino, Federico Taraschi, Giuseppe Visconti, Francesco Cellini, Fabio Marazzi, Valeria Masiello, Liliana Barone Adesi

Abstract read
In one paragraph

Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Marzia SalgarelloUO Chirurgia Plastica, Dipartimento per la Salute della Donna, del Bambino e di Sanità Pubblica - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Valentina Sara PinoUniversità Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy. valentina.pino013@gmail.com.ORCID 0000-0002-5706-6639
Federico TaraschiResidency Program in Plastic Surgery, Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Giuseppe ViscontiUO Chirurgia Plastica, Dipartimento per la Salute della Donna, del Bambino e di Sanità Pubblica - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Francesco CelliniUOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia… - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Fabio MarazziUOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia… - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Valeria MasielloUOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia… - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.
Liliana Barone AdesiUO Chirurgia Plastica, Dipartimento per la Salute della Donna, del Bambino e di Sanità Pubblica - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore" - Largo A. Gemelli 8, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasingly popular, prepectoral breast reconstruction preserves the pectoralis major muscle's anatomy and function. Although polyurethane-coated implants in this context have yielded encouraging results, their interplay with postmastectomy radiation therapy (PMRT) is not well-documented, particularly considering PMRT's known adverse effects on implant-based reconstructions. The study aimed to evaluate the aesthetic outcomes and radiation therapy (RT) damage in patients undergoing prepectoral reconstruction with polyurethane-coated implants receiving PMRT, as well as the influence of mastectomy flap thickness on RT side effects.

methodsIn 47 patients receiving immediate breast reconstruction with prepectoral polyurethane-coated implants followed by PMRT, aesthetic results were assessed using the Likert scale, and RT damage was scored with the LENT-SOMA scale. The study retrospectively analyzed the impact of different RT techniques (3D vs. IMRT) and examined the correlation between mastectomy flap thickness and RT adverse effects.

resultsAt 12-month follow-up, the mean Likert score for patients treated with IMRT/VMAT was 13.06 (SD: 2.55) compared to 11.79 (SD: 2.37) for those treated with the 3D technique. LENT-SOMA scores were 1.46 (SD: 1.13) for IMRT/VMAT and 3.11 (SD: 1.41) for 3D. A negative linear correlation was found between mastectomy flap thickness and RT damage.

conclusionsPreliminary findings are favorable for the use of prepectoral polyurethane-coated implants in immediate breast reconstruction with PMRT, particularly when using IMRT and in patients with thicker mastectomy flaps. Level III, therapeutic study. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Breast ImplantationBreast ImplantsBreast NeoplasmsMammaplastyMastectomyPolyurethanesAdultAgedCoated Materials, BiocompatibleCohort StudiesEstheticsFemaleFollow-Up StudiesHumansMiddle AgedPectoralis MusclesCoated Materials, BiocompatiblePolyurethanesAdjuvant radiotherapyBreast reconstructionPolyurethane implantsPrepectoral breast reconstruction

Identifiers

PMID40841797
PMCPMC12916999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.