SynthesisMolecular psychiatry2025
Are behavioural and inflammatory profiles different according to type of stressor, developmental stage, and sex in rodent models of depression? A systematic review.
Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe onset and persistence of major depressive disorder (MDD) are influenced by various stressors, but the specific impact of different stress types, developmental stages, and sex on behavioural and inflammatory profiles remains unclear. GOAL AND
methodsWe conducted a PRISMA-adhering comprehensive review to systematically examine rodent models of depression and determine how physical, psychological, and physiological stressors - at different developmental stages and across sexes - affect depressive-like behaviours and inflammatory responses.
resultsUtilizing data from Medline, EMBASE, PsycINFO, and Scopus from March 1966 to July 2024, our systematic review of 4886 studies indicate that distinct stressors elicit unique cytokine profiles and behavioural outcomes, with significant variability observed across different developmental stages and between sexes.
conclusionsThe methodological inconsistencies and varying quality of reporting identified by this systematic review highlight the necessity for a consensus for standardized protocols in preclinical studies. Understanding these differences is crucial for developing more effective and personalized strategies for the prevention and treatment of MDD.
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