Evidence map›Paper›PMID 40841707›Full record

ArticleActa pharmacologica Sinica2026

ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m

Kai-Ting Wang, Shuai Yang, Zi-Han Zhao, Chun-Hua Rui, Si-Yun Shen, Dan Cao, Lin-Na Guo, Shan-Hua Tang, Lei Chen, Hong-Yang Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Hypoxia-mediated mJournal of translational medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kai-Ting Wang *Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Shuai Yang *Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Zi-Han Zhao *The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Chun-Hua Rui *Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Si-Yun ShenThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Dan CaoThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Lin-Na GuoThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Shan-Hua TangThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Lei ChenThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China. chenlei@smmu.edu.cn.
Hong-Yang WangDepartment of Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. hywangk@vip.sina.com.
Xin-Yao QiuDepartment of Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. xinyao_qiu@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA m

Indexed as

AdenosineAlkB Homolog 5, RNA DemethylaseCarcinoma, HepatocellularLiver NeoplasmsSTAT1 Transcription FactorAnimalsCarcinogenesisHumansMaleMiceMice, Inbred C57BLMice, KnockoutAdenosineALKBH5 protein, humanALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseN-methyladenosineStat1 protein, mouseSTAT1 Transcription FactorALKBH5epigenetic regulationFOXA3hepatocellular carcinomam6ASTAT1

Identifiers

PMID40841707
PMCPMC12764892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.