ReviewPediatric research2026
The gut-brain ConNECtion: exploring the developmental impact of necrotizing enterocolitis on the neonatal brain.
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Long-Term Growth and Neurodevelopmental Outcomes in Children with Cerebral Palsy: A Nationwide Population-Based Study.Children (Basel, Switzerland) · 2026Article
- Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction.World journal of clinical pediatrics · 2026Review
- Mechanisms and consequences of NEC-induced brain injury in premature infants: understanding a silent affliction.Pediatric research · 2026Article
- Surgical Necrotising Enterocolitis (S-NEC): Where We Stand Today: A Narrative Review.Journal of clinical medicine · 2026Review
- Neurodevelopmental impairment in infants with necrotizing enterocolitis: a comprehensive review of mechanisms, outcomes, and emerging strategies.World journal of pediatric surgery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease within premature infants, posing a significant concern to infants admitted to the neonatal intensive care unit. In those patients who overcome the disease, there are significant long-term effects that include gastrointestinal effects as well as neurodevelopmental deficits. The pathogenesis of necrotizing enterocolitis and its related brain injury that results in these neurodevelopmental deficits is complex and multifaceted, with much research supporting the idea that NEC-induced inflammation is a major cause of brain injury. Thus, management plans for patients with NEC should include an approach geared towards the reduction of associated complications, such as brain injury. This review is focused on exploring our current understanding of the pathophysiology behind NEC and related brain injury and involvement. IMPACT: This review synthesizes current research on NEC-induced inflammation as a major contributor to brain injury, offering a unified perspective on how gastrointestinal disease can lead to neurodevelopmental deficits in preterm infants.
Indexed as
Identifiers
40841674What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.