Evidence map›Paper›PMID 40841659›Full record

ArticleJournal of nanobiotechnology2025

Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways.

Yi Chang, Xue Zhang, Shuo Zhang, Ge Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi Chang *Department of Anesthesiology, the First Hospital of China Medical University, Nanjingbei Street 155#, Shenyang, 110001, Liaoning Province, China.
Xue Zhang *Department of Gynecology, the First Hospital of China Medical University, Nanjingbei Street 155#, Shenyang, 110001, Liaoning Province, China.
Shuo ZhangDepartment of Anesthesiology, the First Hospital of China Medical University, Nanjingbei Street 155#, Shenyang, 110001, Liaoning Province, China. zhangshuo1005@sina.com.ORCID http://orcid.org/0009-0000-7810-8685
Ge QuDepartment of Anesthesiology, the First Hospital of China Medical University, Nanjingbei Street 155#, Shenyang, 110001, Liaoning Province, China. 546653916@qq.com.ORCID http://orcid.org/0009-0006-4259-0311

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developmental neurotoxicity (DNT) induced by sevoflurane exposure poses significant risks to pediatric anesthesia, yet effective protective strategies remain limited. Here, we developed self-assembling Angiopep-2/SIRT1 nanoparticles (Ang/SIRT1-NPs) with favorable biocompatibility and brain-targeting properties. Through in vitro and in vivo studies, we demonstrate that Ang/SIRT1-NPs effectively alleviate sevoflurane-induced neuronal apoptosis, neuroinflammation, and dendritic spine loss. Multi-omics analyses identified SIRT1-mediated suppression of necroptosis and oxidative stress pathways as key mechanisms underlying neuroprotection. Behavioral assays further confirmed improved cognitive and motor function in nanoparticle-treated mice. Our findings highlight the potential of Ang/SIRT1-NPs as a promising neuroprotective strategy for preventing anesthesia-related DNT and support their translational application in pediatric neuroprotection.

Indexed as

Blood-Brain BarrierNanoparticlesNecroptosisNeurotoxicity SyndromesPeptidesSevofluraneSirtuin 1AnimalsApoptosisHumansMaleMiceMice, Inbred C57BLMultiomicsNeuronsNeuroprotective AgentsAngiopep-2Neuroprotective AgentsPeptidesSevofluraneSirtuin 1Angiopep-2/SIRT1 nanoparticlesDevelopmental neurotoxicityMulti-omicsNecroptosisSevoflurane

Identifiers

PMID40841659
PMCPMC12369234

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.