Evidence map›Paper›PMID 40841637›Full record

ArticleBMC oral health2025

Development and verification of a convolutional neural network-based model for automatic mandibular canal localization on multicenter CBCT images.

Xiao Pan, Chengtao Wang, Xuhui Luo, Qi Dong, Haiyang Sun, Wentao Zhang, Hongyan Qu, Runzhi Deng, Zitong Lin

Abstract readMulticenter Study
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao PanDepartment of Dentomaxillofacial Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Zhong Yang Road 30, Nanjing, Jiangsu Province, 210008, China.
Chengtao WangDepartment of Dentomaxillofacial Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Zhong Yang Road 30, Nanjing, Jiangsu Province, 210008, China.
Xuhui LuoDepartment of Dentomaxillofacial Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Zhong Yang Road 30, Nanjing, Jiangsu Province, 210008, China.
Qi DongDepartment of Dentomaxillofacial Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Zhong Yang Road 30, Nanjing, Jiangsu Province, 210008, China.
Haiyang SunSchool of Computer and Software, Nanjing Vocational University of Industry Technology, Nanjing, 210023, China.
Wentao ZhangShanghai Bondent Technology Co., Ltd, Shanghai, 201800, China.
Hongyan QuShanghai Bondent Technology Co., Ltd, Shanghai, 201800, China.
Runzhi DengDepartment of General Dentistry, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China. doctord@163.com.
Zitong LinDepartment of Dentomaxillofacial Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Zhong Yang Road 30, Nanjing, Jiangsu Province, 210008, China. linzitong_710@163.com.

Funding

"2015" Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School, Medical School of Nanjing University No. 0223A204the High-Level Hospital Construction Project of Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University No. 0224C011
6 · The paper itself

Abstract

objectivesDevelopment and verification of a convolutional neural network (CNN)-based deep learning (DL) model for mandibular canal (MC) localization on multicenter cone beam computed tomography (CBCT) images.

methodsIn this study, a total 1056 CBCT scans in multiple centers were collected. Of these, 836 CBCT scans of one manufacturer were used for development of CNN model (training set: validation set: internal testing set = 640:360:36) and an external testing dataset of 220 CBCT scans from other four manufacturers were tested. The convolution module was built using a stack of Conv + InstanceNorm + LeakyReLU. Average symmetric surface distance (ASSD) and symmetric mean curve distance (SMCD) were used for quantitative evaluation of this model for both internal testing data and partial external testing data. Visual scoring (1-5 points) were performed to evaluate the accuracy and generalizability of MC localization for all external testing data. The differences of ASSD, SMCD and visual scores among the four manufacturers were compared for external testing dataset. The time of manual and automatic MC localization were recorded.

resultsFor the internal testing dataset, the average ASSD and SMCD was 0.486 mm and 0.298 mm respectively. For the external testing dataset, 86.8% CBCT scans' visual scores ≥ 4 points; the average ASSD and SMCD of 40 CBCT scans with visual scores ≥ 4 points were 0.438 mm and 0.185 mm respectively; there were significant differences among the four manufacturers for ASSD, SMCD and visual scores (p < 0.05). And the time for bilateral automatic MC localization was 8.52s (± 0.97s).

conclusionsIn this study, a CNN model was developed for automatic MC localization, and external testing of large sample on multicenter CBCT images showed its excellent clinical application potential.

Indexed as

Cone-Beam Computed TomographyMandibleNeural Networks, ComputerConvolutional Neural NetworksDeep LearningHumansCone beam computed tomographyConvolutional neural networkLocalizationMandibular canal

Identifiers

PMID40841637
PMCPMC12369139

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.