ArticleBMC pulmonary medicine2025
Obesity indicators and female asthma risk: the mediating role of white blood cell count based on NHANES data analysis.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of general and central obesity with asthma attacks: A cross-sectional study based on NHANES 2021-2023.Pakistan journal of medical sciences · 2026Article
- Associations of inflammatory burden index with the prevalence and mortality of asthma in adults: a population based study.Journal of thoracic disease · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
objectiveThis study used data from the 2009–2018 National Health and Nutrition Examination Survey (NHANES) to examine the associations between obesity indicators (body mass index [BMI] and body roundness index [BRI]), the inflammatory marker white blood cell count (WBC), and asthma in women. Furthermore, it explored the potential mediating role of WBC in the relationships between BMI, BRI, and asthma.
methodsThis cross-sectional study included 3,792 eligible female participants. Logistic regression, restricted cubic spline (RCS), nonlinear curve fitting, threshold effect analysis, and mediation analysis were applied to evaluate the associations of BMI, BRI, and WBC with asthma.
resultsWeighted analyses showed that women with asthma had significantly higher BMI, BRI, and WBC levels compared to those without asthma (all P < 0.001). After adjusting for all potential confounders, these indicators remained significantly associated with asthma risk. Quartile-based analysis indicated that women in the highest quartile (Q4) of BMI, BRI, and WBC had a significantly higher risk of asthma. RCS and nonlinear curve fitting analyses supported nonlinear associations between these indicators and asthma, suggesting potential threshold effects. Mediation analysis demonstrated that WBC partially mediated the associations between BMI, BRI, and asthma risk.
conclusionThis study identified significant and nonlinear associations between BMI, BRI, WBC, and asthma risk in women. WBC was shown to play a partial mediating role in these relationships, providing new evidence for understanding the inflammatory mechanisms underlying obesity-related asthma.
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