Evidence map›Paper›PMID 40841552›Full record

ArticleNature communications2025

Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin.

Woo Seok Yang, Seu Ha Kim, Minsang Kim, Hejeong Shin, Juyeon Lee, Alexander Sandmann, Ohkmae K Park, Nico Dissmeyer, Hyun Kyu Song

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Woo Seok YangDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.ORCID http://orcid.org/0000-0002-0022-0295
Seu Ha KimDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.
Minsang KimDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.
Hejeong ShinDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.ORCID http://orcid.org/0009-0001-8895-4508
Juyeon LeeDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.
Alexander SandmannDepartment of Plant Physiology and Protein Metabolism Laboratory, University of Osnabruck, Osnabruck, Germany.
Ohkmae K ParkDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea.ORCID http://orcid.org/0000-0002-0234-6908
Nico DissmeyerDepartment of Plant Physiology and Protein Metabolism Laboratory, University of Osnabruck, Osnabruck, Germany.ORCID http://orcid.org/0000-0002-4156-3761
Hyun Kyu SongDepartment of Life Sciences, Korea University, Seongbuk-gu, Seoul, South Korea. hksong@korea.ac.kr.ORCID http://orcid.org/0000-0001-5684-4059

Funding

National Research Foundation of Korea (NRF) RS-2020-NR049540National Research Foundation of Korea (NRF) RS-2021-NR056525National Research Foundation of Korea (NRF) RS-2021-NR056577National Research Foundation of Korea (NRF) RS-2022-NR067411National Research Foundation of Korea (NRF) RS-2025-00521009
6 · The paper itself

Abstract

PROTEOLYSIS1 (PRT1), an N-recognin of Arabidopsis thaliana, recognizes the N-terminal aromatic hydrophobic residue (Tyr/Phe/Trp) of its substrates and ubiquitylates them for degradation by the ubiquitin-proteasome system. Herein, we report the structures of the ZZ domain of PRT1 (PRT1

Indexed as

ArabidopsisArabidopsis ProteinsUbiquitin-Protein LigasesBinding SitesCrystallography, X-RayDegronsHydrophobic and Hydrophilic InteractionsModels, MolecularProtein BindingProtein DomainsProteolysisSubstrate SpecificityUbiquitinationArabidopsis ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40841552
PMCPMC12370974

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.