ArticleNature communications2025
Changes in cellular composition shape the inductive properties of Hensen's Node.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dissecting planar and vertical organiser signals in early chick neural development.Development (Cambridge, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The establishment of the vertebrate body plan is orchestrated by the organizer, a specialized group of cells with inductive properties that guide axial specification during early development. In avian embryos, organizer cells reside within Hensen's node, a transient structure located at the tip of the primitive streak. Despite its pivotal role during gastrulation, the cellular architecture of the Hensen's node remains poorly understood. Here, we show that Hensen's node is composed of two transcriptionally and functionally distinct organizer populations. In addition to anterior GSC-expressing cells associated with head induction, we identify a posterior population co-expressing organizer and mesodermal genes. These posterior cells exhibit trunk-inducing activity when transplanted into naïve tissue. Our findings reveal that the organizer is a dynamic and spatially compartmentalized structure, and that temporal changes in the relative abundance of anterior and posterior populations underlie shifts in its inductive capacity, ensuring coordinated patterning along the body axis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.