Evidence map›Paper›PMID 40841525›Full record

ArticleNature communications2025

Visualization of enantiorecognition by excited-state conformation modulation.

Zizhao Huang, Ying Hu, Jie Sun, Zhenyi He, Tao Jiang, He Tian, Xiang Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zizhao Huang *Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Ying Hu *Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Jie SunKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Zhenyi HeKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Tao JiangKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0003-4008-0802
He TianKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0003-3547-7485
Xiang MaKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. maxiang@ecust.edu.cn.ORCID http://orcid.org/0000-0002-8679-4491

Funding

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 22125803, T2488302, 22020102006 and 22408106
6 · The paper itself

Abstract

Chiral purity is crucial in life sciences, emphasizing the importance of precise enantiomeric identification and the development of analytical techniques. Here, we design functional dyes with visual chiral recognition capabilities by introducing recognition units 2-amino-1,2-diphenylethanol into vibration-induced emission molecules. The unambiguous differentiation in luminescent colors upon binding to enantiomers facilitates the efficient recognition of enantiomers and the analysis of enantiomeric excess. The chiral recognition process originates from co-assembly under charge-aided hydrogen bonding interactions, which is significantly impacted by the steric hindrance effect, and further affects the planarization of the excited state conformation of the dye. This co-assembly process precisely amplifies the dynamics at the molecular level into macroscopic observable signals for real-time, highly sensitive recognition. Furthermore, we establish a sophisticated optical analysis system by correlating Red-Green-Blue values and CIE coordinates to analyze the enantiomeric excess of chiral molecules. This work opens a distinct avenue for visual chiral recognition and inspires the development of advanced optical materials in chiral sensing chemistry.

Identifiers

PMID40841525
PMCPMC12371091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.