ArticleNature methods2025
A versatile miniature two-photon microscope enabling multicolor deep-brain imaging.
Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Simultaneous two- and three-photon multiplane imaging across cortical layers in freely moving mice.Nature methods · 2026Article
- Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain.The European journal of neuroscience · 2026Article
- Learning shapes neural codes for sensory-motor integration in the tail of the striatum.bioRxiv : the preprint server for biology · 2026Article
- Open-Source Platform for Adjustable Training Regimes in Freely Moving and Head-Fixed Mice.eNeuro · 2026Article
- High-speed neural imaging with multiplexed miniaturized two-photon microscopy.Cell reports methods · 2025Article
- Wide-field fluorescence navigation system for efficient miniature multiphoton imaging in freely behaving animals.Neurophotonics · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Here we present FHIRM-TPM 3.0, a 2.6 g miniature two-photon microscope capable of multicolor deep-brain imaging in freely behaving mice. The system was integrated with a broadband anti-resonant hollow-core fiber featuring low transmission loss, minimal dispersion from 700 nm to 1,060 nm and high tolerance of laser power. By correcting chromatic and spherical aberrations and optimizing the fluorescence collection aperture, we achieved cortical neuronal imaging at depths exceeding 820 μm and, using a GRIN lens, hippocampal Ca
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Registered trials
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