Evidence map›Paper›PMID 40841485›Full record

ArticleEuropean biophysics journal : EBJ2025

Optimizing electroporation via pulse modulation: a molecular dynamics study.

Shahariar Emon, Al Amin, Md Hossain, Shovon Saha, Md Asaduzzaman, Md Lokman Hossen, Mohammad Abu Sayem Karal, Hiromitsu Takaba, Md Khorshed Alam

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In one paragraph

Article in European biophysics journal : EBJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shahariar EmonDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.ORCID http://orcid.org/0009-0006-8322-8239
Al AminDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.
Md HossainDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.
Shovon SahaDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.
Md AsaduzzamanDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.
Md Lokman HossenDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh.
Mohammad Abu Sayem KaralDepartment of Physics, Bangladesh University of Engineering and Technology, Dhaka, 1000, Bangladesh.
Hiromitsu TakabaDepartment of Environmental Chemistry and Chemical Engineering, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano Hachioji, Tokyo, 192-0015, Japan.
Md Khorshed AlamDepartment of Physics, University of Barishal, Barishal, 8200, Bangladesh. dmkalam@bu.ac.bd.ORCID http://orcid.org/0000-0002-3925-4900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efficient molecular transport via reversible electroporation requires sustained existence of the pore without causing irreversible cellular damage. In this study, we used molecular dynamics simulations to investigate pore formation during electroporation, and we characterized the transition to hydrophilic pores. Our simulations reveal that during the hydrophilic state, the reapplication of an electric field, even at reduced magnitudes, extends the pore duration while maintaining structural integrity. Furthermore, we established that the pore size can be controlled by regulating the intervals between successive electric field pulses, offering precise control over membrane permeabilization. These findings provide a foundation for fine-tuning electroporation protocols, enabling customized permeabilization strategies based on the properties of the molecules to be delivered. This approach has the potential to significantly improve the efficacy of targeted drug delivery and gene therapy. It also creates new possibilities for precise and controlled cellular manipulation in therapeutic contexts.

Indexed as

ElectroporationMolecular Dynamics SimulationHydrophobic and Hydrophilic InteractionsHydrophilic poreMolecular dynamicsMolecular transportPulse intervalReversible electroporation

Identifiers

PMID40841485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.