Evidence map›Paper›PMID 40841477›Full record

ArticleNature neuroscience2025

Stable cortical body maps before and after arm amputation.

Hunter R Schone, Roni O Maimon-Mor, Mathew Kollamkulam, Malgorzata A Szymanska, Craig Gerrand, Alexander Woollard, Norbert V Kang, Chris I Baker, Tamar R Makin

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. In conversation with Jennifer Collinger.Nature neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. [Technological advances in amputation medicine].Chirurgie (Heidelberg, Germany) · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hunter R SchoneInstitute of Cognitive Neuroscience, University College London, London, UK. schonehunter@gmail.com.ORCID http://orcid.org/0000-0001-8496-2319
Roni O Maimon-MorInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID http://orcid.org/0000-0001-5262-9976
Mathew KollamkulamInstitute of Cognitive Neuroscience, University College London, London, UK.ORCID http://orcid.org/0000-0002-8191-5063
Malgorzata A SzymanskaMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Craig GerrandDepartment of Orthopaedic Oncology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.
Alexander WoollardPlastic Surgery Department, Royal Free Hospital NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-7917-6353
Norbert V KangPlastic Surgery Department, Royal Free Hospital NHS Trust, London, UK.
Chris I BakerLaboratory of Brain & Cognition, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Tamar R MakinInstitute of Cognitive Neuroscience, University College London, London, UK. tamar.makin@mrc-cbu.cam.ac.uk.ORCID http://orcid.org/0000-0002-5816-8979

Funding

Learning and plasticity in the human brainZIAMH002893 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BAKER, CHRIS · 2009 to 2025
$6.8M
Using Neuroprosthetics to Promote Plasticity in Cortical Motor CircuitsF32MH139145 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hunter Schone · 2024 to 2026
$161k
Intramural NIH HHS ZIA MH002893NIMH NIH HHS F32 MH139145NINDS NIH HHS L30 NS145938RCUK | Medical Research Council (MRC) MC_UU_00030/10U.S. Department of Health & Human Services | National Institutes of Health (NIH) F32MH139145U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) ZIAMH 002893Wellcome TrustWellcome Trust (Wellcome) 215575/Z/19/Z
6 · The paper itself

Abstract

The adult brain's capacity for cortical reorganization remains debated. Using longitudinal neuroimaging in three adults, followed before and up to 5 years after arm amputation, we compared cortical activity elicited by movement of the hand (before amputation) versus phantom hand (after amputation) and lips (before and after amputation). We observed stable cortical representations of both hand and lips in primary sensorimotor regions. By directly quantifying activity changes across amputation, we demonstrate that amputation does not trigger large-scale cortical reorganization.

Indexed as

Amputation, SurgicalArmBrain MappingCerebral CortexPhantom LimbAdultFemaleHandHumansMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID40841477
PMCPMC12477700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.