ArticleArchives of gynecology and obstetrics2025
Common chromosomal aneuploidy testing using non-invasive trophoblast retrieval and isolation from the cervix (TRIC) in pregnant women.
Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trophoblast Enrichment by Maternal Immune-Cell Depletion Using CD45 and CD56 Surface Markers in Trophoblast Retrieval and Isolation from the Cervix (TRIC).Diagnostics (Basel, Switzerland) · 2026Article
- Trophoblast Retrieval from the Cervix (TRIC) Across Early Gestation: A Multi-Method Assessment of Extravillous Trophoblast Recovery.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
purposeNon-invasive prenatal diagnosis (NIPD) for aneuploidy has been developed to overcome the limitations of non-invasive prenatal testing (NIPT). NIPT, which analyzes cell-free fetal DNA (cffDNA) in the maternal blood, can only detect a few aneuploidies, such as trisomies 13, 18, and 21. Trophoblast retrieval and isolation from the cervix (TRIC) is an alternative method that separates trophoblasts from endocervical cells using a Papanicolaou smear for NIPD. Here, we report the application of fetal cells obtained from the uterine cervix using a non-invasive cervical cytobrush during the first trimester of pregnancy for diagnosing trisomies 13, 18, and 21, and sex chromosome anomalies.
methodsTrophoblast cells were isolated from the cervical fluid samples of nine pregnant women diagnosed with aneuploidy between the 5th and 20th weeks of gestation using magnetic nanoparticles with a human leukocyte antigen-G antibody.
resultsFluorescence in situ hybridization analysis of the isolated trophoblast cells identified aneuploidies in all nine samples, which was consistent with conventional prenatal genetic testing. The proportion of trisomic cells was between 14.35 and 23.8%, indicating that the isolated cells comprised some maternal cells.
conclusionsIn summary, we successfully identified aneuploidies using TRIC, suggesting its potential as a non-invasive prenatal genetic testing method. However, the efficiency of recovering trophoblast cells from TRIC remains to be elucidated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.