Evidence map›Paper›PMID 40841454›Full record

ArticleScientific reports2025

Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography.

Matteo Pavone, Laetitia Rebiere, Lise Lecointre, Emma Carles, Clément Tondon, Pauline Le Van Quyen, Barbara Seeliger, Diana Giannarelli, Thomas Lampert, Nicolò Bizzarri and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matteo PavoneIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France. matteopavone.21@gmail.com.
Laetitia RebiereIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France.
Lise LecointreIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France.
Emma CarlesDepartment of Gynecologic Surgery, University Hospitals of Strasbourg, Strasbourg, France.
Clément TondonDepartment of Pathology, University Hospitals of Strasbourg, Strasbourg, France.
Pauline Le Van QuyenDepartment of Pathology, University Hospitals of Strasbourg, Strasbourg, France.
Barbara SeeligerIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France.
Diana GiannarelliBiostatistics Unit, Scientific Directorate Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Thomas LampertICube, UMR 7357, CNRS, INSERM U1328 RODIN, University of Strasbourg, Strasbourg, France.
Nicolò BizzarriDipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Giovanni ScambiaDipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Cherif AkladiosDepartment of Gynecologic Surgery, University Hospitals of Strasbourg, Strasbourg, France.
Alina NicolaeDepartment of Pathology, University Hospitals of Strasbourg, Strasbourg, France.
Denis QuerleuIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France.
Aïna VenkatasamyIHU Strasbourg, Institute of Image-Guided Surgery, 1 place de l'Hôpital, Strasbourg CEDEX, 67091, France.

Funding

AI-DIAL ANR-22-CE17-0019-01
6 · The paper itself

Abstract

Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in < 10 min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2 mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.

Indexed as

Genital Neoplasms, FemaleLymphatic MetastasisLymph NodesTomography, Optical CoherenceAdultAgedFemaleHumansMicroscopyMiddle Aged

Identifiers

PMID40841454
PMCPMC12371015

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.