Evidence map›Paper›PMID 40841420›Full record

ArticleScientific reports2025

Elemental and micromorphological analysis of ion releasing restoration/carious dentin interface.

Alaa Esmat Abdelsalam, Hoda Saleh Ismail, Hamdi Hosni Hamama

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alaa Esmat AbdelsalamConservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID https://orcid.org/0009-0007-5862-0105
Hoda Saleh IsmailConservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID https://orcid.org/0000-0001-8369-4041
Hamdi Hosni HamamaConservative Dentistry Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. hamdy_hosny@mans.edu.eg.ORCID https://orcid.org/0000-0003-3205-345X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the current study was to evaluate elemental analysis and micromorphological patterns at the interfaces between tooth substrates either sound or demineralized dentin and ion-releasing restorations, including conventional glass ionomer and ion-releasing composite. The evaluation was conducted immediately (after 24 h) and after six months of artificial saliva storage. A total of 48 sound human premolars were used in this study. The premolars were randomly divided into two groups based on substrate type: sound and demineralized dentin (n = 24). Each substrate group was further subdivided into two subgroups according to restoration type: a conventional glass ionomer (Equia Forte HT) and an ion-releasing composite (ACTIVA-Bioactive Restorative) (n = 12). Each restoration subgroup was further divided according to aging condition: whether tested immediately after 24 h or after storage for six months in artificial saliva (n = 6). Specimens were sectioned buccolingually and longitudinally into two halves. For elemental analysis, one-half of each sectioned specimen was investigated using energy dispersive X-ray spectroscopy (EDX). Four elements (Ca, P, Al, and Si) were specifically examined at three different sites: dentin, hybrid layer, and restoration. For micromorphological patterns, two representative specimens from the second half of sectioned teeth were randomly selected to be observed under scanning electron microscope (SEM). EDX data were tabulated and subjected to statistical analysis, with a significance level set at p < 0.05. Kruskal-Wallis test revealed no statistically significant differences in distribution of the four elements across different tooth substrates or aging times. However, significant differences were observed based on the site factor. SEM micrographs revealed an ion-exchange zone in aged Equia Forte specimens and crystal-like structure deposition in artificially carious dentin bonded to ACTIVA. It has been concluded that both conventional glass ionomer restorative material and ion-releasing composite highlighted their bioactive behavior by demonstrating their potential ability to remineralize the demineralized dentin, reinforcing their promise as effective restorative options for dentin remineralization.

Indexed as

Dental CariesDental Restoration, PermanentDentinBicuspidComposite ResinsGlass Ionomer CementsHumansSaliva, ArtificialSpectrometry, X-Ray EmissionComposite ResinsGlass Ionomer CementsSaliva, ArtificialArtificial caries-affected dentinConventional glass ionomerDentin demineralizationElemental analysisIon-releasing compositeMicromorphological patterns

Identifiers

PMID40841420
PMCPMC12371074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.