Evidence map›Paper›PMID 40841371›Full record

ArticleNature communications2025

Optical focusing into scattering media via iterative time reversal guided by absorption nonlinearity.

Manxiu Cui, S Süleyman Kahraman, Lihong V Wang

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Manxiu CuiCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
S Süleyman KahramanCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Lihong V WangCaltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA. LVW@caltech.edu.ORCID http://orcid.org/0000-0001-9783-4383

Funding

The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
High-speed panoramic 3D photoacoustic computed tomography of the breastR35CA220436 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WANG, LIHONG · 2018 to 2024
$6.4M
NCI NIH HHS R35 CA220436NIBIB NIH HHS P41 EB031772
6 · The paper itself

Abstract

Guide star-assisted time-reversal enables deep optical focusing in scattering media such as biological tissue, overcoming the diffusion limit of light. However, in practice, guide stars formed using contrast agents or ultrasonic modulation naturally occupy regions much larger than the optical resolution, thus limiting their effectiveness. We propose and experimentally demonstrate a time-reversal focusing mechanism in scattering media that achieves focusing to a single speckle grain without the need for point-like guide stars. We exploit optical absorption nonlinearity as a light-induced perturbation to create virtual guide stars. The back-scattered fields in response to high- and low-intensity illuminations are subtracted after scaling to synthesize the field from the dominant speckle grains in the medium. We use this time-reversed field as the incident illumination in subsequent iterations. The focusing is achieved despite the extended layer of nonlinear absorber via a positive feedback loop that favors higher-intensity speckle grains, converging to a single virtual guide star at the optical resolution. We also demonstrate that by adding a phase ramp in each iteration, this focus can be gradually steered beyond the memory effect range.

Identifiers

PMID40841371
PMCPMC12370915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.