ArticleNature communications2025
Optical focusing into scattering media via iterative time reversal guided by absorption nonlinearity.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Rapid wavefront shaping using an optical gradient acquisition.Nature communications · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
Guide star-assisted time-reversal enables deep optical focusing in scattering media such as biological tissue, overcoming the diffusion limit of light. However, in practice, guide stars formed using contrast agents or ultrasonic modulation naturally occupy regions much larger than the optical resolution, thus limiting their effectiveness. We propose and experimentally demonstrate a time-reversal focusing mechanism in scattering media that achieves focusing to a single speckle grain without the need for point-like guide stars. We exploit optical absorption nonlinearity as a light-induced perturbation to create virtual guide stars. The back-scattered fields in response to high- and low-intensity illuminations are subtracted after scaling to synthesize the field from the dominant speckle grains in the medium. We use this time-reversed field as the incident illumination in subsequent iterations. The focusing is achieved despite the extended layer of nonlinear absorber via a positive feedback loop that favors higher-intensity speckle grains, converging to a single virtual guide star at the optical resolution. We also demonstrate that by adding a phase ramp in each iteration, this focus can be gradually steered beyond the memory effect range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.