Trial reportTranslational psychiatry2025
Modulating salience network connectivity through olfactory nerve stimulation.
Trial report in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cang-Ai Volatile Oil Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-like Symptoms in Rats by Regulating NT/Trk Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Causal relationships between somatic movement, brain structures, and mental well-being: A multi-stage Mendelian randomization study.Psychological medicine · 2026Article
- A Prefrontal Neuromodulation Route for Post-Traumatic Olfactory Dysfunction: A Perspective Supported by Recovery During Left-DLPFC rTMS.Brain sciences · 2026Article
- Alterations of the amygdala in post-COVID olfactory dysfunction.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Depression is associated with reduced functional connectivity within the brain's salience network and its strengthened interactions with the default mode network (DMN). Modification of this clinical pattern is challenging. Leveraging the direct neural pathways from olfactory processing regions to the salience network, we explored the effects of electrical stimulation of the olfactory mucosa on brain connectivity. In a randomized, blinded within-subject design, 45 healthy individuals received olfactory or trigeminal nerve stimulation followed by resting-state fMRI. Olfactory stimulation resulted in a significant increase in functional connectivity between the salience network and the piriform cortex - a primary olfactory structure. Importantly, this stimulation increased functional connectivity within the salience network and weakened connectivity between the salience network and the DMN. These findings suggest that olfactory stimulation may modulate connectivity patterns implicated in depression, offering a novel potential minimal invasive therapeutic strategy. However, as these results were obtained from a healthy cohort, further studies are required to evaluate the efficacy in individuals with depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.