Evidence map›Paper›PMID 40841357›Full record

ArticleNature communications2025

Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women.

Jovia L Nierenberg, Aaron W Adamson, Donglei Hu, Scott Huntsman, Carmina Patrick, Min Li, Linda Steele, Shu Tao, Yuan Chun Ding, Barry Tong and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Jovia L NierenbergDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Aaron W AdamsonDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Donglei HuDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0351-001X
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Carmina PatrickDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-8248-818X
Min LiDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Linda SteeleDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Shu TaoIntegrative Genomics Shared Resource, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5177-6771
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Barry TongDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yiwey ShiehDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0159-7748
Laura FejermanDepartment of Public Health Service, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0003-3179-1151
Stephen B GruberDepartment of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-8656-7822
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Esther M JohnDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0001-9136-1175
Gabriela Torres-MejíaInstituto Nacional de Salud Pública, Cuernavaca, Mexico.
Charité RickerDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeffrey N WeitzelDivision of Precision Prevention, The University of Kansas Comprehensive Cancer Center, Kansas City, KS, USA.ORCID http://orcid.org/0000-0001-6714-092X
Elad ZivDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA. Elad.ziv@ucsf.edu.ORCID http://orcid.org/0000-0002-2324-2884
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5053-0390

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Prospective Study of Breast Cancer SurvivorshipR01CA105274 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUSHI, LAWRENCE H · 2004 to 2014
$19.9M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Core-001U01CA164920 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Irene Andrulis, Sarah Violet Colonna · 2018 to 2026
$17.0M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCERR01CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1993 to 2002
$4.5M
Germline and Tumor Genomic Analyses of Breast Cancer in LatinasR01CA184585 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NEUHAUSEN, SUSAN L., ZIV, ELAD · 2014 to 2018
$4.2M
Admixture Mapping for Breast Cancer in LatinasR01CA120120 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2007 to 2011
$2.8M
Biological implications of breast cancer protective variants in Latin Americanwomen with high Indigenous American ancestryR01CA204797 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEJERMAN, LAURA · 2016 to 2020
$1.9M
NCATS NIH HHS KL2 TR001870NCI NIH HHS K08 CA237829NCI NIH HHS K24 CA169004NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063446NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA105274NCI NIH HHS R01 CA120120NCI NIH HHS R01 CA184585NCI NIH HHS R01 CA204797NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA164920NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA164920U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K24CA169004U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA120120U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA184585
6 · The paper itself

Abstract

Breast cancer (BC) is one of the most common cancers globally. Genetic testing facilitates screening and informs targeted risk-reduction and treatments. However, genes included in testing panels are from European-ancestry studies. We conducted a pooled case-control analysis in self-identified Hispanic/Latina women (4178 cases and 4344 controls), using whole exome sequencing and a targeted panel. We tested the association of loss of function (LoF) variants with overall, estrogen receptor (ER)-positive, and ER-negative BC risk. Using logistic regression, we found a strong association of LoF variants in FANCM with ER-negative BC (p = 4.1 × 10

Indexed as

Breast NeoplasmsGenetic Predisposition to DiseaseHispanic or LatinoReceptors, EstrogenAdultAgedCase-Control StudiesDNA HelicasesExome SequencingFanconi Anemia Complementation Group N ProteinFemaleHumansLoss of Function MutationMiddle AgedDNA HelicasesFANCM protein, humanFanconi Anemia Complementation Group N ProteinPALB2 protein, humanReceptors, Estrogen

Identifiers

PMID40841357
PMCPMC12370925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.