ArticleACS biomaterials science & engineering2025
Hybrid Chitosan/PCL Shape Memory Scaffolds with Potential for Bone Regeneration and Infection Resistance.
Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- PCL/Chitosan/Bioglass Hybrid Composite Shape Memory Scaffolds With Accelerated Degradation and Enhanced Bioactivity.Macromolecular materials and engineering · 2026Article
- Impact of temperature and humidity on the structural and biocompatibility of 3D-Printed PLA scaffolds for bone regeneration.Scientific reports · 2026Article
- Advanced Design Concepts for Shape-Memory Polymers in Biomedical Applications and Soft Robotics.Polymers · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
We have previously developed a regenerative engineering approach to repair irregularly shaped craniomaxillofacial bone defects utilizing "self-fitting" shape memory polymer (SMP) scaffolds based on cross-linked poly(ε-caprolactone) (PCL). However, a slow rate of degradation may hinder neotissue infiltration, and a lack of innate antimicrobial activity creates vulnerability to postoperative infection stemming from biofilm formation. Introduction of chitosan (CS), a hydrophilic natural polymer with known antimicrobial behavior, to PCL SMP scaffolds could provide a synergistic combination of desirable properties. Herein, for the first time, we report the development of hybrid (i.e., formed from a synthetic and a naturally derived polymer) CS/PCL SMP scaffolds. A series of eight highly porous PCL/CS-
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Registered trials
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