Evidence map›Paper›PMID 40841319›Full record

ArticleBiomacromolecules2025

Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma.

Odair Braz Júnior, Aline Miranda Cristal, Daniel de Lima Bellan, Gustavo Rodrigues Rossi, Stellee Marcela Petris Biscaia, Camila Laís Gonçalves Ribeiro, Jacqueline Gonçalves Dos Santos, Anderson Fraga da Cruz, João Luiz Aldinucci Buzzo, Helyn Barddal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Odair Braz JúniorCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Aline Miranda CristalCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Daniel de Lima BellanCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Gustavo Rodrigues RossiCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Stellee Marcela Petris BiscaiaCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Camila Laís Gonçalves RibeiroCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Jacqueline Gonçalves Dos SantosCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Anderson Fraga da CruzCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
João Luiz Aldinucci BuzzoCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Helyn BarddalBiochemistry Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Thales R CiprianiBiochemistry Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Marcelo Dias-BaruffiSchool of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, 14040-903, Brazil.
Edvaldo da Silva TrindadeCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Fernanda Fogagnoli SimasCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.
Carolina Camargo de OliveiraCell Biology Department, Universidade Federal do Paraná (UFPR), Curitiba, 81.531-980, Brazil.ORCID 0000-0002-6129-2508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most aggressive skin cancer, with a high metastatic potential and limited treatment options in advanced stages. Polysaccharides are promising antitumor agents, and therefore, this study investigated a galactomannan from guar gum hydrolysis (GGH) and its sulfated derivative (GGHS) for their antimelanoma and immunostimulatory effects. GGH shares structural similarity with DAVANAT, a galectin-1 ligand with anticolorectal cancer activity, while GGHS has anticoagulant properties, like heparin used in cancer patients.

Indexed as

Antineoplastic AgentsMannansMelanomaMelanoma, ExperimentalAnimalsCell Line, TumorCell ProliferationGalactansGalactoseHumansMicePlant GumsReactive Oxygen SpeciesAntineoplastic AgentsGalactansgalactomannanGalactoseguar gumMannansPlant GumsReactive Oxygen Species

Identifiers

PMID40841319
PMCPMC12421689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.