ArticleAJNR. American journal of neuroradiology2025
Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2025Article
- Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
background and purposeProlonged venous transit (PVT) on time-to-maximum (Tmax) perfusion maps has been associated with worse outcomes in patients with acute ischemic stroke due to anterior circulation large-vessel occlusion (AIS-LVO). The qualitative nature of PVT assessment introduces potential variability, and its reproducibility has not been systematically evaluated. MATERIALS AND
methodsIn a retrospective study of patients with confirmed AIS-LVO, 2 board-certified neuroradiologists independently reviewed pretreatment Tmax maps to assess PVT in the posterior superior sagittal sinus and torcula. One reader repeated the assessment after 24 weeks at minimum. Interobserver and intraobserver variability were evaluated with Cohen unweighted κ coefficients.
resultsAmong 194 patients, median age was 70 years (interquartile range, 62-79), and 57% were women. Interobserver agreement was substantial (κ = 0.79; 95% CI, 0.69-0.88), reflecting concordant classification in 178 of 194 patients. Intraobserver agreement was also strong (κ = 0.87; 95% CI, 0.79-0.94), with initial and repeat evaluations differing in 11 cases.
conclusionsQualitative PVT assessment demonstrated substantial interobserver and almost perfect intraobserver reliability. These findings support the use of PVT as a consistent marker of impaired venous outflow in AIS-LVO. Future studies should explore automated or semiquantitative methods to further improve reproducibility and enhance clinical utility.
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