Evidence map›Paper›PMID 40841148›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Prospective Multicenter Evaluation of [

Anthime Flaus, Elise Levigoureux, Julie Haesebaert, Claire Briet, Frederic Castinetti, Justine Cristante, Delphine Drui, Natacha Germain, Luigi Maione, Frederic Illouz and 15 more

Registry-linked trialAbstract readMulticenter StudyComparative StudyClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03346954 (Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03346954 nacompletednot on this map

Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease

TypeinterventionalSponsorHospices Civils de LyonRan2017 to 2020Enrolled33ConditionsCushing's DiseaseArms[11C]-Methionine PET/MRI
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Functional pituitary adenoma imaging.Reviews in endocrine & metabolic disorders · 2026
    Review
  2. Article
  3. The clinical value of [Pituitary · 2026
    Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Anthime FlausNuclear Medicine Department, Hospices Civils de Lyon, Lyon, France; anthime.flaus@chu-lyon.fr.
Elise LevigoureuxLyon Neuroscience Research Center, CNRS UMR5292, INSERM, U1028, Université Claude Bernard Lyon 1, Lyon, France.
Julie HaesebaertResearch on Healthcare Performance, INSERM, Université Claude Bernard Lyon 1, Lyon, France.
Claire BrietDepartment of Endocrinology, Reference Center for Rare Pituitary Diseases, Angers University Hospital, Angers, France.
Frederic CastinettiMarseille Medical Genetics, INSERM, UMR1251, Institut MarMaRa, Department of Endocrinology, Reference Center for Rare Pituitary Diseases, Hôpital La Conception APHM, Aix Marseille University, Marseille, France.
Justine CristanteIRIG Biosanté, INSERM, UMR1292, CEA, CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France.
Delphine DruiDepartment of Endocrinology Diabetology and Nutrition, L'institut du Thorax, CHU de Nantes, Nantes University, Nantes, France.
Natacha GermainDepartment of Endocrinology, Diabetes, Metabolism and Eating Disorders, University Hospital of Saint-Etienne, Saint-Etienne, France.
Luigi MaionePhysiologie et Physiopathologie Endocriniennes, INSERM, UMR-S1185, Service d'Endocrinologie et des Maladies de la Reproduction, Hôpital Bicêtre APHP, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Frederic IllouzDepartment of Endocrinology, Reference Center for Rare Pituitary Diseases, Angers University Hospital, Angers, France.
Emmanuel SonnetService Diabétologie-Endocrinologie, CHRU Brest, Brest, France.
Igor TauveronService d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Ines MeridaLyon Neuroscience Research Center, CNRS UMR5292, INSERM, U1028, Université Claude Bernard Lyon 1, Lyon, France.
Sophie LancelotLyon Neuroscience Research Center, CNRS UMR5292, INSERM, U1028, Université Claude Bernard Lyon 1, Lyon, France.
Nicolas CostesLyon Neuroscience Research Center, CNRS UMR5292, INSERM, U1028, Université Claude Bernard Lyon 1, Lyon, France.
Alexandre VasiljevicDepartment of Neuropathology, Hospices Civils de Lyon, Bron, France.
Lucien MarchandService d'Endocrinologie, Hôpital Saint Joseph Saint Luc, Lyon, France.
Sylvie RodeCentre de Consultation de la Sauvegarde, Lyon, France.
Mireille Bertholon-GregoireClinique du Renaison, Roanne, France.
Guillaume CritonService de Radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.
Véronique LaprasService de Radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.
François CottonService de Radiologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.
Emmanuel JouanneauSkull Base and Pituitary Unit, Department of Neurosurgery B, Neurological Hospital, Lyon, France.
Claire BournaudNuclear Medicine Department, Hospices Civils de Lyon, Lyon, France.
Gerald RaverotUniversité Claude Bernard Lyon 1, Villeurbann, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional small pituitary neuroendocrine tumors (PitNETs) of the corticotroph type lead to Cushing disease (CD), a condition associated with significant morbidity and increased mortality. Pituitary MRI is the primary imaging modality used to localize the tumor, but it is inconclusive in up to 30% of cases. Accumulating retrospective evidence suggests that [

Indexed as

AdenomaMagnetic Resonance ImagingMethionineMultimodal ImagingNeuroendocrine TumorsPituitary ACTH HypersecretionPituitary NeoplasmsPositron-Emission TomographyAdultCarbon RadioisotopesFemaleHumansMaleMiddle AgedProspective StudiesSensitivity and SpecificityCarbon-11carbon-11 methionineCarbon RadioisotopesMethionine[11C]methionineamino acidbraincorticotrophPET/MRI

Identifiers

PMID40841148
PMCPMC12487729

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.