Evidence map›Paper›PMID 40840956›Full record

ArticleSaudi medical journal2025

Investigating the role of genetic variations of

Muhammad U Afzal, Naam B Adeeb, Nur F Musa, Dzul A Noor, Nur Aizati Athirah Binti Daud

Abstract read
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In one paragraph

Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad U AfzalFrom School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Naam B AdeebFrom School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Nur F MusaFrom School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Dzul A NoorFrom School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Nur Aizati Athirah Binti DaudFrom School of Pharmaceutical Sciences (Afzal, Noor, Daud), Universiti Sains Malaysia, Penang; from the Human Genome Centre (Adeeb, Musa, Daud), School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia; and from the College of Medicine (Adeeb), Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.ORCID https://orcid.org/0000-0003-4336-9468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the allele frequency and associations between the presence of single nucleotide polymorphisms (SNP) in the

methodThe study included 64 subjects from a previous genetic association study among male patients who were on atorvastatin. The study was carried out at HUSM, Kelantan, Malaysia from December 2023 to October 2024. The patients were split into 2 groups, each consisting of 32 subjects such as controlled (LDL level <3 mmol/L) and uncontrolled (LDL level >3 mmol/L). After genotyping each participant, the influence on their lipid profile was determined.

resultsThe genotype frequency of genes

conclusionThe allele frequency of the heterozygous group was higher in both studied SNPs. The variant allele of gene

Indexed as

AtorvastatinCholesterol 7-alpha-HydroxylaseLipidsAdultATP Binding Cassette Transporter, Subfamily BGene FrequencyGenotypeHumansMalaysiaMaleMiddle AgedPolymorphism, Single NucleotideABCB1 protein, humanAtorvastatinATP Binding Cassette Transporter, Subfamily BCholesterol 7-alpha-HydroxylaseCYP7A1 protein, humanLipidsatorvastatinCYP7A1 (rs3808607) GeneGene ABCB1 (rs1045642)HDLLDLSNPTGs

Identifiers

PMID40840956
PMCPMC12376158

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