Evidence map›Paper›PMID 40840949›Full record

Observational studySaudi medical journal2025

Prevalence and clinical features of laryngopharyngeal reflux in adults with chronic tonsillitis.

Yahya A Fageeh, Marwan F Alnofaie, Muhanna A Alhusayni, Ahmed A Aljemyie, Lama S Alqurashi, Rayan A Alolayani, Rayan H Alaseeri, Abdullah N Al-Rasheedi

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yahya A FageehFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0002-7104-7055
Marwan F AlnofaieFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Muhanna A AlhusayniFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Ahmed A AljemyieFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Lama S AlqurashiFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Rayan A AlolayaniFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Rayan H AlaseeriFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Abdullah N Al-RasheediFrom the Department Surgery (Fageeh, Alhusayni, Aljemyie, Alqurashi, Alolayani, Alaseeri), College of Medicine, Taif University, from the Department of Otorhinolaryngoloy (Alnofaie), King Faisal Medical complex, Taif, and from the Department of Otolaryngology and Head and Neck Surgery (Al-Rasheedi), College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the prevalence and clinical presentation of laryngopharyngeal reflux (LPR) among adults with chronic tonsillitis and examine how effective reflux treatments are for these patients.

methodsA prospective observational study was conducted at a tertiary referral hospital from March 2024 to January 2025 on adult participants diagnosed with chronic tonsillitis who presented with tonsillar inflammation and sore throat. The participants were evaluated before and after treatment with proton pump inhibitors (PPIs) and dietary and lifestyle modifications for 3 months. The assessment tools used were as follows: visual analog scale (VAS) for sore throat, tonsillar grade, reflux symptom index (RSI), and reflux finding score (RFS).

resultsThe study included 112 patients, of whom 81 (72.3%) had LPR based on RSI and RFS measurements. Of the participants who met the criteria for LPR diagnosis, 78 received 3 months of treatment. Of the patients who completed the study treatment protocol, 64.1% reported complete relief from sore throat. Mean VAS scores significantly reduced from 2.69 to 0.97 (

conclusionThis study demonstrates a significant association between chronic tonsillitis and LPR. Treating LPR in patients with chronic tonsillitis with PPIs and dietary and lifestyle modifications can improve LPR and tonsillar inflammation, potentially reducing unnecessary tonsillectomies.

Indexed as

Laryngopharyngeal RefluxTonsillitisAdultChronic DiseaseFemaleHumansMaleMiddle AgedPharyngitisPrevalenceProspective StudiesProton Pump InhibitorsProton Pump Inhibitorschronic tonsillitislaryngopharyngeal refluxlifestyle modificationproton pump inhibitorsreflux finding scorereflux symptom indexsore throatvisual analog scale

Identifiers

PMID40840949
PMCPMC12376165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.