ArticleRenal failure2025
Frailty and peripheral neuropathy in hemodialysis patients: clinical and electrophysiological correlations.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diabetic Foot Ulceration in Dialysis-Dependent End-Stage Kidney Disease: A Systematic Review of Epidemiology, Clinical Outcomes and Mortality Risk.Diabetes/metabolism research and reviews · 2026Pooled it
- Electromyographic findings and frailty in hemodialysis vs peritoneal dialysis patients.Renal failure · 2026Article
- Ten tips to reduce fracture risk by non-pharmacologic interventions in CKD-associated osteoporosis.Clinical kidney journal · 2026Review
- Symptom Burden After Dialysis Initiation and Its Association With Hospitalization.Kidney medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is highly prevalent in chronic kidney disease patients and associated with mortality. We investigated the relationship between frailty and peripheral neuropathy in hemodialysis patients.
methodsWe enrolled 70 maintenance hemodialysis patients and assessed physical frailty using the five-criteria Fried frailty index. Motor and sensory nerve conduction studies were performed on median, ulnar, peroneal, tibial, and sural nerves. Neuropathy severity was measured using the Total Neuropathy Score (TNS). ANCOVA was performed to control for age and cardiovascular disease as confounders.
resultsPatients were categorized as non-frail (
conclusionsFrailty and peripheral neuropathy demonstrate a strong, independent association in hemodialysis patients that persists after controlling for major confounders. This relationship exists regardless of diabetes status, suggesting peripheral nerve dysfunction is an integral component of frailty in this population. Early recognition could enable targeted interventions to improve outcomes in vulnerable hemodialysis patients.
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