Evidence map›Paper›PMID 40840861›Full record

ArticleThe Journal of allergy and clinical immunology2025

Artificial intelligence biomarker detects high-risk childhood asthma subgroup for respiratory infections and exacerbations.

Young J Juhn, Chung-Il Wi, Euijung Ryu, Katherine S King, Sunghwan Sohn, Elham Sagheb, Greg Jenkins, David Watson, Miguel A Park, Sergio E Chiarella and 13 more

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Young J JuhnDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Precision Population Science Lab, Mayo Clinic, Rochester, Minn. Electronic address: Juhn.young@mayo.edu.
Chung-Il WiDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Precision Population Science Lab, Mayo Clinic, Rochester, Minn.
Euijung RyuDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn.
Katherine S KingDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn.
Sunghwan SohnDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, Minn.
Elham SaghebDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, Minn.
Greg JenkinsDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn.
David WatsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn.
Miguel A ParkDivision of Allergic Diseases, Mayo Clinic, Rochester, Minn.
Sergio E ChiarellaDivision of Allergic Diseases, Mayo Clinic, Rochester, Minn.
Hirohito KitaDivision of Allergic Diseases, Mayo Clinic, Scottsdale, Ariz.
Mir AliSanford Children's Hospital, Sioux Falls, SD.
W Charles HuskinsDivision of Pediatric Infectious Diseases, Mayo Clinic, Rochester, Minn.
Elizabeth H RistagnoDivision of Pediatric Infectious Diseases, Mayo Clinic, Rochester, Minn.
Imad AbsahDivision of Pediatric Gastroenterology, Mayo Clinic, Rochester, Minn.
Charles GroseDepartment of Pediatrics, Division of Infectious Diseases/Virology, University of Iowa, Iowa City, Iowa.
Kathy IhrkeDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Precision Population Science Lab, Mayo Clinic, Rochester, Minn.
Elizabeth A KrusemarkDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Precision Population Science Lab, Mayo Clinic, Rochester, Minn.
Thanai PongdeeDivision of Allergic Diseases, Mayo Clinic, Rochester, Minn.
Björn NordlundKarolinska Institutet, Women's and Children's Health and Lung-Allergy Department, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Carla M DavisDepartment of Pediatrics and Child Health, Howard University, Washington, DC.
Robert J PignoloDepartment of Medicine, Divisions of Hospital Internal Medicine, Endocrinology, and Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, Minn.
Hongfang LiuMcWilliams School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Tex. Electronic address: hongfang.liu@uth.tmc.edu.

Funding

Identification and characterization of children with asthma-associated comorbidities through computational and immune phenotypingR01HL126667 · NHLBI · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, LIU, HONGFANG · 2015 to 2022
$4.3M
Enhanced Ascertainment of Asthma Status Via Natural Language ProcessingR21AI116839 · NIAID · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, WU, STEPHEN TZE-INN · 2015 to 2016
$437k
Secondary use of EMR for residency training in asthma care and documentationR21AI142702 · NIAID · MAYO CLINIC ROCHESTER · PI JUHN, YOUNG J, SOHN, SUNGHWAN · 2019 to 2020
$437k
NHLBI NIH HHS R01 HL126667NIAID NIH HHS R21 AI116839NIAID NIH HHS R21 AI142702
6 · The paper itself

Abstract

backgroundAsthma is associated with an increased risk of acute respiratory infections (ARI). Little is known about whether natural language processing (NLP)-powered digital biomarkers can identify a high-risk asthma subgroup for ARI during early childhood.

objectiveWe assessed whether a digital biomarker could identify a high-risk subgroup of childhood asthma for ARI.

methodsWe applied validated NLP algorithms for Predetermined Asthma Criteria (NLP-PAC) and Asthma Predictive Index (NLP-API) to electronic health records of the 1997-2016 Mayo Clinic Birth Cohort. We categorized the cohort into 4 subgroups: both criteria positive (NLP

resultsThere were 22,370 eligible subjects (51% male and 81% White). The NLP

conclusionNLP

Indexed as

Artificial IntelligenceAsthmaRespiratory Tract InfectionsAlgorithmsBiomarkersChild, PreschoolElectronic Health RecordsFemaleHumansInfantMaleNatural Language ProcessingRisk FactorsBiomarkersartificial intelligenceAsthmacohortepidemiologyinfectionNLPpediatricphenotypingprecisionrisksubgroup

Identifiers

PMID40840861
PMCPMC12513160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.