Evidence map›Paper›PMID 40840720›Full record

ArticleAnnals of vascular surgery2025

The Two-Decade Experience of Oncovascular Reconstruction in Patients with Retroperitoneal Sarcoma.

Anita Zahiri, Arash Fereydooni, Emily Eshraghian, Milan Ho, Daniel Delitto, Byrne Lee, George A Poultsides, Jeffrey A Norton, E John Harris, Elizabeth L George

Abstract read
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In one paragraph

Article in Annals of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Anita ZahiriDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA; Warren Alpert Medical School of Brown University, Providence, RI.
Arash FereydooniDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA.
Emily EshraghianDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA.
Milan HoDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA.
Daniel DelittoDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA.
Byrne LeeDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA.
George A PoultsidesDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA.
Jeffrey A NortonDivision of Surgical Oncology, Department of Surgery, Stanford University, Stanford, CA.
E John HarrisDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA.
Elizabeth L GeorgeDivision of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA. Electronic address: lizzyg@stanford.edu.

Funding

Stanford Cardiovascular Summer Research Training Program for Medical StudentsT35HL160496 · NHLBI · STANFORD UNIVERSITY · PI America Facundo, Joseph C. Wu · 2022 to 2026
$574k
NHLBI NIH HHS T35 HL160496
6 · The paper itself

Abstract

backgroundSurgical resection remains the cornerstone of sarcoma treatment; however, tumor involvement of major vasculature presents challenges. Multidisciplinary approaches incorporating vascular surgery have expanded feasibility of resection, yet long-term outcome data remain limited.

methodsWe performed a retrospective review of patients with retroperitoneal sarcomas who underwent resection with vascular reconstruction at a tertiary referral center from 2001 to 2024. Data included demographics, tumor characteristics, operative details, and outcomes including mortality, graft patency, and reinterventions.

resultsA total of 263 vascular procedures were performed in 101 patients (median age 59 years; 52% female). Prior sarcoma resection occurred in 36.3%, 53.5% received chemoradiation, and 41.7% had stage IV disease. The most common histology was leiomyosarcoma (34.7%). Concurrent procedures included nephrectomy (53.5%) and colectomy (36.3%). Thirty-day mortality was 5%, with a 64.4% Clavien-Dindo grade II + complication rate. Median overall survival was 5.9 years. Vascular reintervention occurred in 11.9% of cases. One-year vascular reintervention-free survival was 90.5%, with no 1-year survival difference between patients with (93.3%, n = 84) and without reconstruction thrombosis (81.7%, n = 16; P = 0.454). Univariate analysis associated thrombosis with diabetes, dual antiplatelet therapy, anticoagulation with antiplatelet therapy, iliac vein reconstruction using cryopreserved grafts, and 90-day readmission. On multivariate analysis, only use of cryopreserved grafts for iliac vein reconstruction remained significantly associated with thrombosis (odds ratio (OR) 12.75, 95% confidence interval (CI) 1.68-18.93; P = 0.019).

conclusionOver two decades, vascular reconstructions facilitated complex sarcoma resections with favorable long-term outcomes. Iliac vein reconstructions using cryopreserved grafts carry higher thrombosis risk. Despite the complexity of these cases, the outcomes reflect the effectiveness of multidisciplinary management.

Indexed as

Blood Vessel Prosthesis ImplantationPlastic Surgery ProceduresRetroperitoneal NeoplasmsSarcomaVascular Surgical ProceduresAdultAgedAged, 80 and overBlood Vessel ProsthesisFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk Assessment

Identifiers

PMID40840720
PMCPMC12507452

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.