Evidence map›Paper›PMID 40840683›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2025

Polypharmacy and deprescribing attitudes among stroke survivors: Opportunities for enhanced patient centered care.

Alyssa K Chao, James F Burke, Ran Bi, Chun Chieh Lin, Lesli E Skolarus

Abstract read
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa K ChaoFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
James F BurkeOhio State University, Department of Neurology, Columbus, OH, USA.
Ran BiOhio State University, Department of Neurology, Columbus, OH, USA.
Chun Chieh LinOhio State University, Department of Neurology, Columbus, OH, USA.
Lesli E SkolarusFeinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: lesli.skolarus@northwestern.edu.

Funding

Advancing Community Connections and Calculating Risk to Optimize Stroke Survivorship (ACROSS)R01NS138072 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Lesli Elizabeth Skolarus · 2024 to 2026
$2.1M
NINDS NIH HHS R01 NS138072
6 · The paper itself

Abstract

objectiveThis study aimed to 1) describe the burden of polypharmacy among stroke survivors compared to older adults without a history of stroke and 2) assess their attitudes towards deprescribing.

methodsThis is a cross-sectional study of US Medicare Beneficiaries aged ≥65 who participated in the National Health and Aging Trends Study. Polypharmacy was defined by the number of regular medications reported (no polypharmacy, ≤5; moderate, 6-10; severe, >10). Deprescribing attitudes were elicited from the Medication Attitudes Module. Ordinal and logistic regression assessed the associations between polypharmacy, history of stroke, and deprescribing attitudes, adjusting for falls and comorbidities.

resultsOf the 2073 respondents, 253 reported a prior stroke. Compared to older adults without a history of stroke, stroke survivors were more likely to report polypharmacy (moderate: 39.4 % vs 29.8 %; severe: 22.6 % vs 9.8 %; p < 0.01). Most stroke survivors (87.1 %) and older adults without stroke (89.0 %) would be willing to stop one or more medications. Polypharmacy had the strongest association with favorable attitudes toward deprescribing.

conclusionStroke survivors report greater polypharmacy than older adults without a history of stroke. Both groups overwhelmingly favor deprescribing. Stroke survivors represent a key population that would welcome and benefit from efforts to deprescribe.

Indexed as

DeprescriptionsHealth Knowledge, Attitudes, PracticePatient-Centered CarePolypharmacyStrokeSurvivorsAgedAged, 80 and overAge FactorsCross-Sectional StudiesFemaleHumansMaleMedicareRisk FactorsUnited StatesDeprescribingOlder adultsPolypharmacyStroke survivors

Identifiers

PMID40840683
PMCPMC12720275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.