Evidence map›Paper›PMID 40840304›Full record

ArticleJournal of psychosomatic research2025

Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study.

Kirsten Voorhies, Jess G Fiedorowicz, Abebaw M Yohannes, Gregory L Kinney, Dawn L DeMeo, Elizabeth A Regan, James D Crapo, Edwin K Silverman, Christoph Lange, Karin F Hoth and 1 more

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Article in Journal of psychosomatic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kirsten VoorhiesDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Jess G FiedorowiczThe Ottawa Hospital, Ottawa Hospital Research Institute, and University of Ottawa, Ottawa, Ontario, Canada.
Abebaw M YohannesDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA.
Gregory L KinneyDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth A ReganDepartment of Medicine, National Jewish Health, Denver, CO, USA.
James D CrapoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Christoph LangeDepartment of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Karin F HothDepartment of Psychiatry and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
Sharon M LutzDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. Electronic address: smlutz@hsph.harvard.edu.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
The role of sex in genetic association studies of depressionR01MH129337 · NIMH · HARVARD PILGRIM HEALTH CARE, INC. · PI Sharon Marie Lutz · 2022 to 2026
$2.1M
Mentoring in Patient Oriented Research in Lung Disease through the Lens of Sex as a Biological VariableK24HL171900 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DAWN L DEMEO · 2024 to 2026
$386k
NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS K24 HL171900NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIMH NIH HHS R01 MH129337
6 · The paper itself

Abstract

objectiveExamine clinical and demographic variables associated with new onset depression and anxiety symptoms and assess moderation by sex in COPDGene, a cohort study of current and former smokers at risk for or with chronic obstructive pulmonary disease (COPD).

methodsIn the COPDGene study, 2653 adults had the hospital anxiety (HADS-A) and depression (HADS-D) scales available at phase 2 and 3, as well as clinical and demographic variables available at 2 and non-elevated HADS at phase 2. We defined new onset depression symptoms as HADS-D elevated at phase 3 (HADS-D ≥ 8) versus no new onset as HADS-D not elevated at either phase (HADS-D < 8). New onset anxiety symptoms were defined identically using HADS-A. We used logistic regression models among all participants and stratified by sex and assessed sex interactions for variables associated with the outcome for only one sex.

resultsAmong males, COPD Assessment test (CAT) score was positively associated with new onset depression (β = 0.08, p = 1.9 × 10

conclusionsThese findings highlight the importance of understanding factors that increase risk for depression and anxiety among smokers at risk for or with COPD and are moderated by sex.

Indexed as

AnxietyDepressionPulmonary Disease, Chronic ObstructiveSmokingAgedCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsAnxietyDepressionHospital anxiety and depression scale (HADS)Sex

Identifiers

PMID40840304
PMCPMC12798645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.