Evidence map›Paper›PMID 40840230›Full record

Trial reportESMO open2025

Improving chemotherapy-induced peripheral neuropathy in cancer patients using a combined qigong and self-administered acupressure intervention: a randomized controlled trial.

D S T Cheung, W F Yeung, P H Chau, S Y Chan, W L Chan, C H Yeh, L Lao, Z Zhang, C C Lin

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in ESMO open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07779863 (Caregiver-administered Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease With Blood Amyloid and Tau Biomarkers), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07779863 nanot yet recruitingnot on this mapstarted 2027, after this paper: background citation

Caregiver-administered Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease With Blood Amyloid and Tau Biomarkers: a Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2027 to 2030Enrolled188ConditionsAlzheimer's DiseaseArmsComfy Acupressure for the Elderly, Least acupressure control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

D S T CheungSchool of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR. Electronic address: denisest@hku.hk.
W F YeungSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
P H ChauSchool of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
S Y ChanSchool of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
W L ChanDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
C H YehCizik School of Nursing, The University of Texas Health Science Center at Houston, Houston.
L LaoVirginia University of Integrative Medicine, Vienna, Virginia, USA.
Z ZhangSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
C C LinSchool of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcupressure and qigong are Chinese medicine-based modalities that can work in synergy to improve chemotherapy-induced peripheral neuropathy (CIPN). This study examines the effect of a combined qigong and acupressure intervention on CIPN among cancer patients. PATIENTS AND

methodsThis randomized controlled trial included cancer patients experiencing CIPN. Participants were randomly allocated to intervention and waitlist control groups (1 : 1). The intervention group received a 16-week combined qigong and self-administered acupressure intervention. The primary outcome was self-reported CIPN severity (Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity). Other outcomes included objectively measured CIPN severity (DPNCheck), handgrip strength (dynamometer), physical performance (Short Physical Performance Battery), fall incidence, and health-related quality of life (HRQoL, Functional Assessment of Cancer Therapy-General). Data were collected at baseline, 16 weeks, and 28 weeks. Intention-to-treat analysis was carried out.

resultsThe study randomly assigned 110 patients [mean (standard deviation) age 61.86 years (9.31 years); 49 (89.1%) female], among whom 103 completed the study. After intervention, the reduction in self-reported CIPN severity in the intervention group was significantly larger than in the control group (mean difference = -3.86, 95% confidence interval CI -6.14 to -1.58), P = 0.001). The intervention showed significant benefit in reducing self-reported CIPN severity (group × time P = 0.004), physical performance (group × time P = 0.025), and HRQoL (group × time P < 0.001). The effect on objectively measured CIPN severity, handgrip strength, and fall incidence did not reach statistical significance.

conclusionsA combined qigong and acupressure intervention versus waitlist control significantly improved self-reported CIPN among cancer patients. Incorporating the combined intervention into standard practice is recommended.

Indexed as

AcupressureAntineoplastic AgentsNeoplasmsPeripheral Nervous System DiseasesQigongAgedFemaleHand StrengthHumansMaleMiddle AgedQuality of LifeTreatment OutcomeAntineoplastic Agentsacupressurecancerchemotherapy-induced peripheral neuropathyqigongrandomized controlled trial

Identifiers

PMID40840230
PMCPMC12529305

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.