Evidence map›Paper›PMID 40840012›Full record

ArticleMolecular pharmacology2025

Trace amine-associated receptor 1 agonists differentially regulate dopamine transporter function.

Julia K Huey, Xiao Shi, William E Schutzer, Aaron Janowsky, Atheir I Abbas

Abstract read
In one paragraph

Article in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia K HueyProgram in Physiology and Pharmacology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon.
Xiao ShiResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon.
William E SchutzerResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon; Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.
Aaron JanowskyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon; Research Service, Veterans Affairs Portland Health Care System, Portland, Oregon; Department of Psychiatry, Oregon Health & Science University, Portland, Oregon; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon.
Atheir I AbbasResearch Service, Veterans Affairs Portland Health Care System, Portland, Oregon; Department of Psychiatry, Oregon Health & Science University, Portland, Oregon; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon. Electronic address: abbasat@ohsu.edu.

Funding

BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
NIAAA NIH HHS T32 AA007468NIDA NIH HHS T32 DA007262
6 · The paper itself

Abstract

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor stimulated by trace amines and amphetamine-like psychostimulants. The TAAR1 agonists RO5166017 and RO5256390 have antidepressant- and anxiolytic-like effects in preclinical models, and the TAAR1/partial 5HT

Indexed as

Dopamine Plasma Membrane Transport ProteinsReceptors, G-Protein-CoupledAnimalsDopamineHEK293 CellsHumansMaleMiceOxazolesPhenethylaminesRatsRats, Sprague-DawleyTrace Amine-Associated ReceptorsDopamineDopamine Plasma Membrane Transport ProteinsOxazolesPhenethylaminesReceptors, G-Protein-CoupledRO5166017Trace Amine-Associated ReceptorsAmphetamineDopamine transporterTrace amine–associated receptor 1

Identifiers

PMID40840012
PMCPMC12597562

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.