ArticleScience (New York, N.Y.)2025
Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Compound Ciwujia Granules Attenuate Stress-Induced Anxiety- and Depression-Like Behaviors via Inhibition of TNF-α-Associated Neuroinflammation in the dmPFC.CNS neuroscience & therapeutics · 2026Article
- The frontal cortex in mental disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- A complete genome for the common marmoset.Cell · 2026Article
- Dorsolateral Prefrontal Cortex Circuitry at the Intersection of Cognition and Disease.Biological psychiatry · 2026Review
- Role of α-Synuclein in the Prefrontal Cortex: From Physiological Synaptic Modulation to Synaptic Failure in Parkinson's Disease.Biomedicines · 2026Review
- Altered kinship vocal dynamics in marmosets with valproic acid-induced model of autism.iScience · 2026Article
- A Complete Genome for the Common Marmoset.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal disruption of prefrontal dynamics during affective association in depression: an fNIRS case-control study.BMC psychiatry · 2026Article
- Disrupted synapses: prefrontal cortex-reward circuit dysfunction in stress-induced depression-like behaviors.Frontiers in cellular neuroscience · 2026Review
- Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety.Science (New York, N.Y.) · 2025Article
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Authors and funding
10 authors.
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Abstract
The dorsolateral prefrontal cortex (dlPFC) is a higher-order brain structure targeted for noninvasive stimulation for treatment-resistant depression. Nonetheless, its causal role in emotion regulation is unknown. We discovered that inactivating dlPFC area 46 in marmosets blunts appetitive motivation and heightens threat reactivity. The effects were asymmetric-dependent on the left hemisphere only-and were mediated through projections to pregenual cingulate area 32. The antidepressant ketamine blocked the appetitive motivational deficits through mechanisms within subcallosal cingulate area 25, an area linked with treatment success in dlPFC noninvasive stimulation. Our data uncover an integrated prefrontal network for area 46 that contributes to positive and negative emotion regulation that may be core to our understanding of symptoms and therapeutic strategies for treatment-resistant depression and anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.