ArticlePloS one2025
Investigating the role of FOX gene family in development and stress response in Labeo rohita: A multi-faceted analysis of phylogeny and genome characterization.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrated Biomarker Assessment of Bifenthrin, Chlorpyrifos and Endosulfan Toxicity in Indigenous Carps (Catla catla and Labeo rohita): Oxidative Stress, Genotoxicity and Nuclear Alterations.Veterinary medicine and science · 2026Article
- Behavioral, Hematological, Biochemical, Antioxidant, Histopathological and Micronuclear Abnormality in the Erythrocytes of Ctenopharyngodon idella Exposed to Chromium Chloride Toxicity.Biological trace element research · 2026Article
- Multi-Species Probiotics Improve Health Performance and Alleviate Stress Responses of Rohu (Labeo rohita) in Inland Brackish Water Ponds.Probiotics and antimicrobial proteins · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
The forkhead box (FOX) gene family of transcription factors regulates muscle development, immune responses, and metabolic processes across species. Despite extensive studies on FOX genes in other organisms, their evolutionary and functional roles in Labeo rohita, an economically and ecologically important freshwater fish, remain unclear. Owing to its unique physiological and ecological traits, L. rohita is an ideal model for exploring these roles. Here, we present the first computational analysis of the FOX gene family in L. rohita, identifying 21 FOX genes. Physicochemical analysis revealed that most FOX proteins have a basic nature except for FOX A3, D3, I2, O1, O3, O4, P1, and P2. Instability index analysis indicated that all FOX proteins are unstable (values > 40), while hydrophobicity assessment showed that except FOX O1, all proteins are hydrophobic. Phylogenetic analysis grouped FOX homologs into 11 major clades with other vertebrates. All proteins exhibited structural homogeneity by sharing the Forkhead Box domain. Gene structure comparisons revealed seven duplicated pairs, and Circos analysis demonstrated organization into 20 clusters. This study highlights the critical roles of FOX genes and fills a significant knowledge gap, providing a foundation for future functional and phylogenomic studies with implications for aquaculture and evolutionary biology.
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