ArticlePain2025
Spontaneous pain dynamics characterized by stochasticity in neural recordings of awake humans with chronic pain.
Article in Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contemporary evidence for central nervous system mechanisms underlying chronic pain perception, modulation, and chronification in adults: a scoping review.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- A freestanding submicron electrocorticography electrode array.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
abstractChronic pain is characterized by spontaneous fluctuations in pain intensity, a phenomenon that remains poorly understood. The aim of this study is to elucidate the neural mechanisms underlying pain fluctuations in patients with chronic pain undergoing deep brain stimulation surgery. We recorded local field potentials (LFPs) from pain-processing hub structures, including the ventral posteromedial nucleus of the thalamus, subgenual cingulate cortex, and periventricular and periaqueductal gray, while patients continuously reported their pain levels. Using novel auto-mutual information metrics to analyze LFP stochastic patterns, we found that pain intensity correlated with both increased regularity of spike-like events and greater past-dependency of neural oscillations in the 4- to 15-Hz frequency band. In addition, during periods of higher pain states, we observed enhanced functional connectivity between the examined hub structures and the prefrontal cortex, suggesting a more focused flow of pain-related information within the pain circuit. By characterizing the dynamic nature of pain fluctuations, this study bridges the gap in understanding moment-to-moment pain variations and their underlying neural mechanisms, paving the way for improved chronic pain management strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.